CELA3B - chymotrypsin like elastase 3B Gene

Homo sapiens

Also known as CBPP; ELA3B

Gene ID: 23436 | Gene type: protein coding

About CELA3B

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:21,977,022-21,998,642 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 6 paralogues. Restricted expression toward pancreas (RPKM 10341.0).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, Elastase 3B has little elastolytic activity. Like most of the human elastases, Elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

CELA3B Products(1)

mRNA	Protein	Name
NM_007352.4	NP_031378.1	chymotrypsin-like elastase family member 3B preproprotein

CELA3B Protein Structure

Trypsin

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

chymotrypsin-like elastase family member 3B

cholesterol-binding pancreatic protease

Related Diseases

Diseases

Alias

Exocrine Pancreatic Insufficiency

Pancreatic Steatorrhea

Pancreatic Steatorrhoea	Decreased Tolerance Of Pancreas
Pancreatic Disturbance Of Fat Absorption

Pancreatitis

Mumps Pancreatitis

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Common Bile Duct Disease

Common Bile Duct Diseases

Pancreatic Serous Cystadenoma

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Choledocholithiasis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02458	CELA3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CELA3B	RGD	RGD:1307819
Mus musculus	CELA3B	NCBI	NCBI:67868

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