2. Gene
  3. ABCB9 - ATP binding cassette subfamily B member 9 Gene

ABCB9 - ATP binding cassette subfamily B member 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TAPL; EST122234

Gene ID: 23457 | Gene type: protein coding

About ABCB9

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,918,610-122,975,114 (from NCBI)

This gene has 20 transcripts (splice variants), 209 orthologues and 10 paralogues. Broad expression in testis (RPKM 3.4), brain (RPKM 1.2) and 23 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of Peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

ABCB9 Products(5)

mRNA Protein Name
NM_001243013.2 NP_001229942.1 ABC-type oligopeptide transporter ABCB9 isoform 6
NM_001243014.2 NP_001229943.1 ABC-type oligopeptide transporter ABCB9 isoform 5
NM_019624.4 NP_062570.1 ABC-type oligopeptide transporter ABCB9 isoform 2
NM_019625.4 NP_062571.1 ABC-type oligopeptide transporter ABCB9 isoform 1
NM_203444.4 NP_982269.2 ABC-type oligopeptide transporter ABCB9 isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ABC-type oligopeptide transporter activity IDA
IDA: Inferred from direct assay
15863492 GOA
enables ABC-type peptide transporter activity IDA
IDA: Inferred from direct assay
17977821 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
15863492 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21194361 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18434309 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
18952056 GOA
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
18434309 GOA
Biological Process GO Annotation Evidence Reference Source
NOT involved in antigen processing and presentation of peptide antigen via MHC class I IDA
IDA: Inferred from direct assay
17977821 GOA
involved in peptide metabolic process IDA
IDA: Inferred from direct assay
25646430 GOA
involved in peptide transport IDA
IDA: Inferred from direct assay
15863492 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in early endosome IDA
IDA: Inferred from direct assay
17977821 GOA
NOT located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17977821 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
1101155 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
10748049 GOA
located in lysosome IDA
IDA: Inferred from direct assay
22641697 GOA
located in membrane IDA
IDA: Inferred from direct assay
18434309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCB9 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (190 - 451)

ABC_tran

ABC_tran: ABC transporter (522 - 671)

  • 0
  • 200
  • 400
  • 600
  • 766 a.a.
Protein Preferred Names Protein Names

ABC-type oligopeptide transporter ABCB9

ABC transporter 9 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00056 ABCB9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ABCB9 VGNC VGNC:25467
Rattus norvegicus ABCB9 RGD RGD:620254
Felis catus ABCB9 VGNC VGNC:80417
Mus musculus ABCB9 MGD MGI:1861729
Canis familiaris ABCB9 VGNC VGNC:97182
Macaca mulatta ABCB9 VGNC VGNC:81341