TRAM1 - translocation associated membrane protein 1 Gene

Homo sapiens

Also known as TRAM; PNAS8; TRAMP

Gene ID: 23471 | Gene type: protein coding

About TRAM1

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,573,218-70,608,416 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

TRAM1 Products(3)

mRNA	Protein	Name
NM_001317804.2	NP_001304733.1	translocating chain-associated membrane protein 1 isoform 2
NM_001317805.2	NP_001304734.1	translocating chain-associated membrane protein 1 isoform 3
NM_014294.6	NP_055109.1	translocating chain-associated membrane protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18555783	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cotranslational protein targeting to membrane	IDA IDA: Inferred from direct assay	8616892	GOA
involved in protein insertion into ER membrane	IDA IDA: Inferred from direct assay	8616892	GOA
involved in response to unfolded protein	IMP IMP: Inferred from mutant phenotype	20430023	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18555783	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	8616892	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAM1 Protein Structure

TRAM1

TRAM_LAG1_CLN8

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

translocating chain-associated membrane protein 1

translocating chain-associating membrane protein

TRAM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRAM1	Q15629	BCAP31	Homo sapiens	P51572	Ub Reconstruction	18555783
Intra	TRAM1	Q15629	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	18555783

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meckel Syndrome, Type 2

MKS2	Meckel Syndrome 2
Meckel-Gruber Syndrome, Type 2	Meckel Syndrome Type 2

Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever

Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant

Northern Epilepsy	Neuronal Ceroid Lipofuscinosis 8 Northern Epilepsy Variant
Epmr	Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type
Northern Epilepsy Syndrome	Epilepsy, Progressive, With Mental Retardation
Northern Epilepsy Variant, Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant	Progressive Epilepsy With Mental Retardation, Northern Epilepsy
Cln8 Disease, Northern Epilepsy Variant	Ncl, Northern Epilepsy Variant
Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant	CLN8NE
Ceroid Lipofuscinosis, Neuronal, 8

Orofaciodigital Syndrome Vi

OFD6	Varadi-Papp Syndrome
Varadi Syndrome	Joubert Syndrome With Orofaciodigital Defect
Orofaciodigital Syndrome Type 6	Orofaciodigital Syndrome 6
Oral-Facial-Digital Syndrome, Type Vi	Ofds Vi
Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation	Polydactyly Cleft Lip Palate Psychomotor Retardation
Oral-Facial-Digital Syndrome Type 6	Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome
Polydactyly - Cleft Lip/Palate - Psychomotor Retardation	Váradi Syndrome
Váradi-Papp Syndrome	Joubert Syndrome With Oral-Facial-Digital Syndrome
Oral-Facial-Digital Syndrome 6	Joubert-Orofaciodigital Syndrome
Orofaciodigital Syndrome, Type Vi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14981	TRAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRAM1	VGNC	VGNC:81678
Canis familiaris	TRAM1	VGNC	VGNC:54123
Macaca mulatta	TRAM1	VGNC	VGNC:84131
Bos taurus	TRAM1	VGNC	VGNC:53882
Mus musculus	TRAM1	MGD	MGI:1919515
Rattus norvegicus	TRAM1	RGD	RGD:1359100

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