DAAM2 - dishevelled associated activator of morphogenesis 2 Gene

Homo sapiens

Also known as NPHS24; dJ90A20A.1

Gene ID: 23500 | Gene type: protein coding

About DAAM2

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,792,376-39,904,869 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 23.5), esophagus (RPKM 10.9) and 20 other tissues.

Summary

Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in nervous system development and regulation of Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

DAAM2 Products(2)

mRNA	Protein	Name
NM_001201427.2	NP_001188356.1	disheveled-associated activator of morphogenesis 2 isoform 1
NM_015345.4	NP_056160.2	disheveled-associated activator of morphogenesis 2 isoform 2

DAAM2 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1068 a.a.

Protein Preferred Names

Protein Names

disheveled-associated activator of morphogenesis 2

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 24

NPHS24	Idiopathic Steroid-Resistant Nephrotic Syndrome
Idiopathic Srns	Nephrotic Syndrome 24
Nephrotic Syndrome, Idiopathic, Steroid-Resistant	Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Genetic Srns
Hereditary Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Nephrotic Syndrome
Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive	Srn1

Guillain-Barre Syndrome

Guillain-Barré Syndrome	Acute Inflammatory Polyneuropathy
Gbs	Acute Inflammatory Demyelinating Polyneuropathy
Acute Inflammatory Demyelinating Polyradiculoneuropathy	Acute Infective Polyneuritis
Acute Inflammatory Demyelinating Polyradiculopathy	Acute Postinfectious Polyneuropathy
Infectious Neuronitis	Post-Infectious Polyneuritis
Postinfectious Polyneuritis	Acute Autoimmune Peripheral Neuropathy
Acute Immune-Mediated Polyneuropathy	Acute Inflammatory Neuropathy
Guillain-Barré-Strohl Syndrome	Landry'S Ascending Paralysis
Landry-Guillain-Barre-Strohl Syndrome	Post-Infective Polyneuritis
Acute Infectious Polyneuritis	Fisher Syndrome
Landry-Guillain-Barre Syndrome	Guillain-Barre-Strohl Syndrome
Variant Of Guillain-Barre Syndrome	Variant Of Gbs
Aidp	Acute Idiopathic Demyelinating Polyneuropathy
Gbs, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form	Guillain-Barre Syndrome, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form
Miller Fisher Syndrome

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Apolipoprotein C-Iii Deficiency

Hyperalphalipoproteinemia 2

HALP2

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03509	DAAM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAAM2	VGNC	VGNC:27863
Mus musculus	DAAM2	MGD	MGI:1923691
Felis catus	DAAM2	VGNC	VGNC:61327
Macaca mulatta	DAAM2	VGNC	VGNC:71658
Rattus norvegicus	DAAM2	RGD	RGD:1306128
Canis familiaris	DAAM2	VGNC	VGNC:39757

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