FOLR3 - folate receptor gamma Gene

Homo sapiens

Also known as FR-G; FRgamma; FR-gamma; gamma-hFR

Gene ID: 2352 | Gene type: protein coding

About FOLR3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,135,725-72,139,892 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 27.0), appendix (RPKM 4.9) and 3 other tissues.

Summary

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

FOLR3 Products(2)

mRNA	Protein	Name
NM_000804.4	NP_000795.2	folate receptor gamma isoform 1 precursor
NM_001412270.1	NP_001399199.1	folate receptor gamma isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLR3 Protein Structure

Folate_rec

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

folate receptor gamma

folate receptor 3 (gamma)

FOLR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOLR3	P41439	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	FOLR3	P41439	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FOLR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78766	FOLR3 Protein, Human (HEK293, His)	P41439 (Q23-S245)	≥95%

Related Diseases

Diseases

Alias

Primary Peritoneal Carcinoma

Serous Surface Papillary Carcinoma	Eoppc
Extra-Ovarian Primary Peritoneal Carcinoma	Ppc
Primary Peritoneal Serous Carcinoma	Primary Peritoneal Serous Adenocarcinoma

Choriocarcinoma Of The Testis

Testicular Choriocarcinoma

Subacute Leukemia

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Exudative Vitreoretinopathy 3

EVR3

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05031	FOLR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOLR3	MGD	MGI:95569
Others	FOLR3	NCBI

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