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  3. FOLR3 Protein, Human (HEK293, His)

FOLR3 Protein, Human (HEK293, His)

Cat. No.: HY-P78766
SDS COA Handling Instructions

FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of FOLR3 Protein, Human (HEK293, His) is 223 a.a., with molecular weight of 33-45 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of FOLR3 Protein, Human (HEK293, His) is 223 a.a., with molecular weight of 33-45 kDa.

Background

The FOLR3 protein plays a pivotal role in folate metabolism, binding to folate and reduced folic acid derivatives while facilitating the delivery of 5-methyltetrahydrofolate to the interior of cells. It is noteworthy that the Isoform Short of FOLR3 does not exhibit folate-binding capabilities. This differential binding behavior suggests distinct functional roles for the various isoforms of FOLR3, emphasizing the nuanced regulation of folate transport within cellular processes.

Biological Activity

Human FOLR3 protein captured on CM5 chip can bind Folic acid with an affinity constant of 0.122 nM as detected by SPR assay(Biacore T200).

Species

Human

Source

HEK293

Tag

C-His

Accession

P41439 (Q23-S245)

Gene ID
Molecular Construction
N-term
FOLR3 (Q23-S245)
Accession # P41439
His
C-term
Synonyms
folate receptor 3 (gamma); Folate receptor 3; folate receptor gamma; FOLR3; FR-G; FR-gamma; gamma-Hfr;
Molecular Weight

33-45 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder

Formulation

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

FOLR3 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FOLR3 Protein, Human (HEK293, His)
Cat. No.:
HY-P78766
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