SRRM2 - serine/arginine repetitive matrix 2 Gene

Homo sapiens

Also known as CWF21; Cwc21; 300-KD; SRL300; SRm300; HSPC075

Gene ID: 23524 | Gene type: protein coding

About SRRM2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,752,638-2,771,412 (from NCBI)

This gene has 27 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 88.4), bone marrow (RPKM 86.9) and 25 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity and protein N-terminus binding activity. Involved in mRNA splicing, via spliceosome. Located in Cajal body and nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Biomarker of Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022]

SRRM2 Products(1)

mRNA	Protein	Name
NM_016333.4	NP_057417.3	serine/arginine repetitive matrix protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C2H2 zinc finger domain binding	IDA IDA: Inferred from direct assay	17577209	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17577209	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	17577209	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	29361316	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	17577209	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28062851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM2 Protein Structure

cwf21

0
500
1000
1500
2000
2500
2752 a.a.

Protein Preferred Names

Protein Names

serine/arginine repetitive matrix protein 2

300 kDa nuclear matrix antigen

Related Diseases

Diseases

Alias

Status Epilepticus

Grand Mal Status Epilepticus	Grand Mal Status
Gcse	Generalized Convulsive Status Epilepticus
Se	Epilepsy With Status Epilepticus

Patella, Chondromalacia Of

Chondromalacia Patellae	Chondromalacia Of Patella
Softening Of Articular Cartilage Of Patella	Patellofemoral Pain Syndrome
Patellofemoral Chondromalacia

Idh-Mutant Anaplastic Astrocytoma

Dicer1 Syndrome

Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome	Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome
Ppb Familial Tumor Susceptibility Syndrome	Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome
Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility	Dicer1-Related Pleuropulmonary Blastoma
Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome	Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome
Ppbftds	Doid:0081063

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13787	SRRM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SRRM2	VGNC	VGNC:58613
Rattus norvegicus	SRRM2	RGD	RGD:1310163
Felis catus	SRRM2	VGNC	VGNC:65691
Macaca mulatta	SRRM2	VGNC	VGNC:82248
Canis familiaris	SRRM2	VGNC	VGNC:54071
Mus musculus	SRRM2	MGD	MGI:1923206

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