2. Gene
  3. Dlat - dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) Gene

Dlat - dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DLTA; PDC-E2; 6332404G05Rik

Gene ID: 235339 | Gene type: protein coding

About Dlat

Summary

Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity and identical protein binding activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlat Products(1)

mRNA Protein Name
NM_145614.4 NP_663589.3 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
27621431 MGI
Biological Process GO Annotation Evidence Reference Source
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
17314311 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
9405644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

PDCE2

dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

pyruvate dehydrogenase complex component E2

Recombinant Dlat Proteins

Cat. No. Product Name Accession Purity
HY-P71676 PDCE2 Protein, Mouse (HEK293, His) Q8BMF4 (S86-L642) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03792 DLAT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-116330 Hyperforin / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlat NCBI NCBI:1737