FPGS - folylpolyglutamate synthase Gene

Homo sapiens

Gene ID: 2356 | Gene type: protein coding

About FPGS

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,802,858-127,814,506 (from NCBI)

This gene has 21 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in ovary (RPKM 14.6), fat (RPKM 12.1) and 25 other tissues.

Summary

This gene encodes the folylpolyglutamate synthetase Enzyme. This Enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This Enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

FPGS Products(3)

mRNA	Protein	Name
NM_001018078.2	NP_001018088.1	folylpolyglutamate synthase, mitochondrial isoform b
NM_001288803.1	NP_001275732.1	folylpolyglutamate synthase, mitochondrial isoform c precursor
NM_004957.6	NP_004948.4	folylpolyglutamate synthase, mitochondrial isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tetrahydrofolylpolyglutamate synthase activity	IDA IDA: Inferred from direct assay	3619447	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	25164808	GOA
involved in folic acid-containing compound metabolic process	IDA IDA: Inferred from direct assay	3619447	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	3619447	GOA
involved in tetrahydrofolylpolyglutamate biosynthetic process	IDA IDA: Inferred from direct assay	3619447	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	25164808	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25164808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

folylpolyglutamate synthase, mitochondrial

folylpoly-gamma-glutamate synthetase

Related Diseases

Diseases

Alias

Cutis Laxa, Autosomal Dominant 2

ADCL2	Autosomal Dominant Cutis Laxa 2
Cutis Laxa, Autosomal Dominant, 2	Cutis Laxa, Autosomal Dominant, Type 2

Cutis Laxa, Autosomal Dominant 1

Cutis Laxa, Autosomal Dominant	Autosomal Dominant Cutis Laxa
ADCL1	Adcl
Autosomal Dominant Cutis Laxa 1	Cutis Laxa, Autosomal Dominant, 1
Cutis Laxa, Autosomal Dominant, Type 1

Subacute Leukemia

Childhood Acute Lymphocytic Leukemia

Childhood Acute Lymphoblastic Leukemia	Childhood All
Pediatric Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia Acute Childhood

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14945	Remogliflozin etabonate	Inhibitor	99.81%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122259	AMPte-Glu-γ-Glu		/	Unkown
HY-125316	AMG-151		/	Unkown
HY-D1199	Blue FPG-A trisodium	Antagonist	/	Unkown
HY-RS05083	FPGS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FPGS	VGNC	VGNC:55047
Felis catus	FPGS	VGNC	VGNC:62351
Canis familiaris	FPGS	VGNC	VGNC:40973
Mus musculus	FPGS	MGD	MGI:95576
Macaca mulatta	FPGS	VGNC	VGNC:72815
Rattus norvegicus	FPGS	RGD	RGD:1587713

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