2. Gene
  3. GTPBP4 - GTP binding protein 4 Gene

GTPBP4 - GTP binding protein 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NGB; CRFG; NOG1

Gene ID: 23560 | Gene type: protein coding

About GTPBP4

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:988,434-1,019,932 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 19.5), testis (RPKM 18.5) and 25 other tissues.

Summary

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger Other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

GTPBP4 Products(1)

mRNA Protein Name
NM_012341.3 NP_036473.2 GTP-binding protein 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTP binding IDA
IDA: Inferred from direct assay
17210637 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
17210637 GOA
enables preribosome binding IDA
IDA: Inferred from direct assay
32669547 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17210637 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
17210637 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
17210637 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17210637 GOA
involved in negative regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
17210637 GOA
involved in negative regulation of collagen binding IMP
IMP: Inferred from mutant phenotype
17210637 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
17210637 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
17210637 GOA
involved in regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17210637 GOA
involved in ribosomal large subunit biogenesis IDA
IDA: Inferred from direct assay
32669547 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17210637 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17210637 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17210637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTPBP4 Protein Structure

NOG1

NOG1: Nucleolar GTP-binding protein 1 (NOG1) (235 - 292)

NOGCT

NOGCT: NOGCT (NUC087) domain (394 - 446)

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  • 634 a.a.
Protein Preferred Names Protein Names

GTP-binding protein 4

G protein-binding protein CRFG

GTPBP4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82444 GTPBP4 Antibody (YA2189) WB, IHC-P, IP, FC Human

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 23

COXPD23

Combined Oxidative Phosphorylation Defect Type 23

Oxidative Phosphorylation Deficiency, Combined, Type 23
Melanomatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05911 GTPBP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GTPBP4 RGD RGD:620783
Bos taurus GTPBP4 VGNC VGNC:29710
Felis catus GTPBP4 VGNC VGNC:62737
Canis familiaris GTPBP4 VGNC VGNC:49777
Macaca mulatta GTPBP4 VGNC VGNC:73215
Mus musculus GTPBP4 MGD MGI:1916487