NTSR2 - neurotensin receptor 2 Gene

Homo sapiens

Also known as NTR2

Gene ID: 23620 | Gene type: protein coding

About NTSR2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,658,178-11,670,195 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 9.3).

Summary

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several Other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

NTSR2 Products(5)

mRNA	Protein	Name
XM_005246156.4	XP_005246213.1	neurotensin receptor type 2 isoform X4
XM_017003738.2	XP_016859227.1	neurotensin receptor type 2 isoform X1
NM_012344.4	NP_036476.2	neurotensin receptor type 2
XM_006711877.4	XP_006711940.1	neurotensin receptor type 2 isoform X3
XM_006711876.5	XP_006711939.1	neurotensin receptor type 2 isoform X2

NTSR2 Protein Structure

7tm_1

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

neurotensin receptor type 2

NT-R-2	levocabastine-sensitive neurotensin receptor
neurotensin receptor, type 2

Related Diseases

Diseases

Alias

Alzheimer Disease 14

AD14	Alzheimer'S Disease 14
Alzheimer Disease-14	Alzheimer'S Disease 14, Late Onset

Conduct Disorder

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09641	NTSR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09642	Ntsr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09643	Ntsr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NTSR2	MGD	MGI:108018
Canis familiaris	NTSR2	VGNC	VGNC:44015
Rattus norvegicus	NTSR2	RGD	RGD:70962
Macaca mulatta	NTSR2	VGNC	VGNC:75545
Bos taurus	NTSR2	VGNC	VGNC:32313

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