2. Gene
  3. PLXNB2 - plexin B2 Gene

PLXNB2 - plexin B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MM1; PLEXB2; Nbla00445; dJ402G11.3

Gene ID: 23654 | Gene type: protein coding

About PLXNB2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,274,979-50,307,646 (from NCBI)

This gene has 12 transcripts (splice variants), 318 orthologues and 8 paralogues. Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues.

Summary

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

PLXNB2 Products(24)

mRNA Protein Name
NM_001376864.1 NP_001363793.1 plexin-B2 isoform 1 precursor
NM_001376865.1 NP_001363794.1 plexin-B2 isoform 2 precursor
NM_001376866.1 NP_001363795.1 plexin-B2 isoform 3 precursor
NM_001376867.1 NP_001363796.1 plexin-B2 isoform 3 precursor
NM_001376868.1 NP_001363797.1 plexin-B2 isoform 3 precursor
NM_001376869.1 NP_001363798.1 plexin-B2 isoform 3 precursor
NM_001376870.1 NP_001363799.1 plexin-B2 isoform 3 precursor
NM_001376871.1 NP_001363800.1 plexin-B2 isoform 3 precursor
NM_001376872.1 NP_001363801.1 plexin-B2 isoform 3 precursor
NM_001376873.1 NP_001363802.1 plexin-B2 isoform 3 precursor
NM_001376874.1 NP_001363803.1 plexin-B2 isoform 3 precursor
NM_001376875.1 NP_001363804.1 plexin-B2 isoform 3 precursor
NM_001376876.1 NP_001363805.1 plexin-B2 isoform 3 precursor
NM_001376877.1 NP_001363806.1 plexin-B2 isoform 3 precursor
NM_001376878.1 NP_001363807.1 plexin-B2 isoform 3 precursor
NM_001376879.1 NP_001363808.1 plexin-B2 isoform 3 precursor
NM_001376880.1 NP_001363809.1 plexin-B2 isoform 3 precursor
NM_001376881.1 NP_001363810.1 plexin-B2 isoform 3 precursor
NM_001376882.1 NP_001363811.1 plexin-B2 isoform 3 precursor
NM_001376883.1 NP_001363812.1 plexin-B2 isoform 4 precursor
NM_001376884.1 NP_001363813.1 plexin-B2 isoform 5 precursor
NM_001376885.1 NP_001363814.1 plexin-B2 isoform 5 precursor
NM_001376886.1 NP_001363815.1 plexin-B2 isoform 7 precursor
NM_012401.4 NP_036533.2 plexin-B2 isoform 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15184888 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
29100074 GOA
Biological Process GO Annotation Evidence Reference Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
16122393 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
16122393 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
29100074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB2 Protein Structure

Sema

Sema: Sema domain (35 - 438)

PSI

PSI: Plexin repeat (469 - 516)

TIG

TIG: IPT/TIG domain (803 - 892)

TIG

TIG: IPT/TIG domain (898 - 967)

TIG

TIG: IPT/TIG domain (983 - 1091)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1271 - 1805)

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  • 1500
  • 1838 a.a.
Protein Preferred Names Protein Names

plexin-B2

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Walker-Warburg Syndrome

Hard Syndrome

Walker-Warburg Congenital Muscular Dystrophy

Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

Cod-Md Syndrome

Chemke Syndrome

Hydrocephalus, Agyria And Retinal Dysplasia

Cerebroocular Dysgenesis

Cerebroocular Dysplasia Muscular Dystrophy Syndrome

Hard +/- E Syndrome

Pagon Syndrome

Warburg Syndrome

Hydrocephalus, Agyria, And Retinal Dysplasia

Mddga

Muscular Dystrophy-Dystroglycanopathy , Type A

Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

Wws

Dystrophy, Muscular, Dystroglycanopathy, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10753 PLXNB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLXNB2 RGD RGD:1305495
Mus musculus PLXNB2 MGD MGI:2154239
Felis catus PLXNB2 VGNC VGNC:68919
Canis familiaris PLXNB2 VGNC VGNC:44723
Bos taurus PLXNB2 VGNC VGNC:33062
Macaca mulatta PLXNB2 VGNC VGNC:76188