Aplnr - apelin receptor Gene

Mus musculus

Also known as APJ; Agtrl1; msr/apj

Gene ID: 23796 | Gene type: protein coding

About Aplnr

Chromosome 2: 84,966,569-84,970,267 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 172 orthologues, 9 paralogues and is associated with 26 phenotypes.

Summary

Predicted to enable apelin receptor activity. Involved in several processes, including apelin receptor signaling pathway; circulatory system development; and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Acts upstream of or within regulation of gap junction assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and reproductive system. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Aplnr Products(1)

mRNA	Protein	Name
NM_011784.3	NP_035914.1	apelin receptor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in adult heart development	IMP IMP: Inferred from mutant phenotype	28663440	MGI
involved in aorta development	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in atrioventricular valve development	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in coronary vasculature development	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	23603510	MGI
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28890073	MGI
acts upstream of or within regulation of gap junction assembly	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in vascular associated smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in vasculature development	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	28663440	MGI
involved in venous blood vessel development	IMP IMP: Inferred from mutant phenotype	23603510	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	23603510	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aplnr Protein Structure

7tmA_Apelin_R

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

apelin receptor

G-protein coupled receptor APJ	MSR
angiotensin receptor-like 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2271	MM 54	Inhibitor	99.16%	Unkown
HY-126293	Apelin agonist 1	Agonist	/	Unkown
HY-147751	APJ receptor agonist 6		/	Unkown
HY-RS00823	APLNR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00824	Aplnr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00825	Aplnr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aplnr	NCBI	NCBI:187

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