ALOX12 - arachidonate 12-lipoxygenase, 12S type Gene

Homo sapiens

Also known as LOG12; 12-LOX; 12S-LOX

Gene ID: 239 | Gene type: protein coding

About ALOX12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,996,049-7,010,754 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 5 paralogues. Broad expression in esophagus (RPKM 11.1), skin (RPKM 5.2) and 15 other tissues.

Summary

This gene encodes a member of the Lipoxygenase family of proteins. The encoded Enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded Enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

ALOX12 Products(2)

mRNA	Protein	Name
NM_000697.3	NP_000688.2	polyunsaturated fatty acid lipoxygenase ALOX12
XM_011523780.3	XP_011522082.2	polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate 12(S)-lipoxygenase activity	IDA IDA: Inferred from direct assay	1851637	GOA
enables arachidonate 15-lipoxygenase activity	IDA IDA: Inferred from direct assay	17493578	GOA
enables linoleate 13S-lipoxygenase activity	IDA IDA: Inferred from direct assay	8319693	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10727209	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	17493578	GOA
involved in fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	15111312	GOA
NOT involved in leukotriene A4 metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in leukotriene A4 metabolic process	IDA IDA: Inferred from direct assay	8250832	GOA
NOT involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	8319693	GOA
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	17493578	GOA
involved in lipoxin A4 biosynthetic process	IDA IDA: Inferred from direct assay	8250832	GOA
involved in lipoxin B4 biosynthetic process	IDA IDA: Inferred from direct assay	8250832	GOA
involved in lipoxygenase pathway	IDA IDA: Inferred from direct assay	8319693	GOA
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23578768	GOA
involved in unsaturated fatty acid metabolic process	IDA IDA: Inferred from direct assay	23504711	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8319693	GOA
located in cytosol	IDA IDA: Inferred from direct assay	8912711	GOA
located in membrane	IDA IDA: Inferred from direct assay	8912711	GOA
located in sarcolemma	IDA IDA: Inferred from direct assay	15107407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX12 Protein Structure

PLAT

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

polyunsaturated fatty acid lipoxygenase ALOX12

12S-lipoxygenase	Arachidonate 12-lipoxygenase, 12S-type
arachidonate (12S)-lipoxygenase	arachidonate (15S)-lipoxygenase
arachidonate 15-lipoxygenase,15S-type	linoleate 13S-lipoxygenase
lipoxin synthase 12-LO	platelet 12-LOX
platelet-type 12-lipoxygenase	platelet-type lipoxygenase 12

ALOX12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALOX12	P18054	LMNA	Homo sapiens	P02545	Anti Bait CoIP	10727209
Intra	ALOX12	P18054	LMNA	Homo sapiens	P02545	Y2H	10727209
Intra	ALOX12	P18054	KRT5	Homo sapiens	P13647	Y2H	10727209
Intra	ALOX12	P18054	KRT5	Homo sapiens	P13647	Anti Bait CoIP	10727209

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALOX12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72076	ALOX12 Protein, Human (His)	P18054 (M1-I663)	≥95%

Related Diseases

Diseases

Alias

Erythroleukemia

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Malignant Squamous Cell Tumor
Squamous Carcinoma	Squamous Cell Epithelioma
Squamous Cell Skin Cancer	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Psoriasis

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Toxoplasmosis

Disseminated Toxoplasmosis	Multisystemic Disseminated Toxoplasmosis
Acquired Toxoplasmosis	Toxoplasmosis Disease Or Disorder
Infection By Toxoplasma Gondii	Toxoplasmal
Toxoplasma

Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3	ARCI3
Lamellar Ichthyosis 5	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 5, Formerly	Li5, Formerly
Li5	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive, Type 3

Diabetes Mellitus

Diabetes

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Ichthyosis, Lamellar
Non Bullous Congenital Ichthyosiform Erythroderma	Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form
Ichthyosiform Erythroderma, Congenital, Nonbullous, 1	Collodion Baby
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALOX12	RGD	RGD:1311159
Canis familiaris	ALOX12	VGNC	VGNC:49900
Macaca mulatta	ALOX12	VGNC	VGNC:69795
Mus musculus	ALOX12	MGD	MGI:87998
Bos taurus	ALOX12	VGNC	VGNC:25841
Others	ALOX12	NCBI

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