Scn11a - sodium channel, voltage-gated, type XI, alpha Gene

Mus musculus

Also known as NaN; NaT; NSS2; SNS2; NaV1.9

Gene ID: 24046 | Gene type: protein coding

About Scn11a

Chromosome 9: 119,582,825-119,654,522 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 96 orthologues, 26 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

Summary

Enables voltage-gated Sodium Channel activity. Involved in regulation of sensory perception of pain. Acts upstream of or within sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; liver and biliary system; and reproductive system. Used to study familial episodic pain syndrome 3 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Apr 2022]

Scn11a Products(1)

mRNA	Protein	Name
NM_011887.3	NP_036017.3	sodium channel protein type 11 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11376006	MGI
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	16029194	MGI
enables voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	24036948	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18096591	MGI
involved in action potential	IMP IMP: Inferred from mutant phenotype	30395542	MGI
involved in action potential initiation	IMP IMP: Inferred from mutant phenotype	18270172	MGI
involved in acute inflammatory response	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in artery development	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	22641814	MGI
involved in behavioral response to acetic acid induced pain	IMP IMP: Inferred from mutant phenotype	19931571	MGI
involved in behavioral response to formalin induced pain	IMP IMP: Inferred from mutant phenotype	19931571	MGI
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	19931571	MGI
involved in cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in calcitonin gene-related peptide receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22641814	MGI
involved in cell motility	IMP IMP: Inferred from mutant phenotype	23596386	MGI
involved in cellular response to cold	IMP IMP: Inferred from mutant phenotype	25959819	MGI
involved in chemosensory behavior	IMP IMP: Inferred from mutant phenotype	30395542	MGI
involved in chronic inflammatory response	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	25101983	MGI
involved in detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	25101983	MGI
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	25101983	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	16029194	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	17167076	MGI
involved in mast cell degranulation	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in membrane depolarization during action potential	IMP IMP: Inferred from mutant phenotype	24036948	MGI
involved in micturition	IMP IMP: Inferred from mutant phenotype	19146922	MGI
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	17167076	MGI
involved in reflex	IMP IMP: Inferred from mutant phenotype	17363266	MGI
involved in regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	30557356	MGI
involved in response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in response to cold	IMP IMP: Inferred from mutant phenotype	27224030	MGI
involved in response to cyclophosphamide	IMP IMP: Inferred from mutant phenotype	19146922	MGI
involved in response to heat	IMP IMP: Inferred from mutant phenotype	27224030	MGI
involved in response to high light intensity	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in response to nitric oxide	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in response to pain	IMP IMP: Inferred from mutant phenotype	17167076	MGI
involved in response to prostaglandin E	IMP IMP: Inferred from mutant phenotype	19146922	MGI
involved in response to toxic substance	IMP IMP: Inferred from mutant phenotype	18096591	MGI
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	25959819	MGI
involved in sensory perception of itch	IMP IMP: Inferred from mutant phenotype	30395542	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	24036948	MGI
involved in skeletal muscle organ development	IMP IMP: Inferred from mutant phenotype	32817686	MGI
involved in small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	32817686	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18096591	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	16029194	MGI
involved in thermosensory behavior	IMP IMP: Inferred from mutant phenotype	27224030	MGI
involved in thigmotaxis	IMP IMP: Inferred from mutant phenotype	31534133	MGI
involved in transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	15964986	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in C-fiber	IDA IDA: Inferred from direct assay	16029194	MGI
is active in axon	IDA IDA: Inferred from direct assay	22641814	MGI
located in axon	IDA IDA: Inferred from direct assay	16029194	MGI
is active in axonal growth cone	IDA IDA: Inferred from direct assay	22641814	MGI
is active in cell body	IDA IDA: Inferred from direct assay	31534133	MGI
is active in neuronal cell body	IDA IDA: Inferred from direct assay	17363266	MGI
is active in neuronal cell body	IMP IMP: Inferred from mutant phenotype	23596386	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16029194	MGI
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	24036948	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn11a Protein Structure

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

GPHH

0
300
600
900
1200
1500
1765 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 11 subunit alpha

sensory neuron sodium channel 2	sodium channel protein type XI subunit alpha
sodium channel, voltage-gated, type XI, alpha polypeptide	voltage-gated sodium channel NAV1.9b
voltage-gated sodium channel subunit alpha Nav1.9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12522	SCN11A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12523	Scn11a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12524	Scn11a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990502	Anti-SCN11a/Nav1.9 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn11a	NCBI	NCBI:11280

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