CLDN15 - claudin 15 Gene

Homo sapiens

Gene ID: 24146 | Gene type: protein coding

About CLDN15

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,232,094-101,238,820 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 22 paralogues. Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

CLDN15 Products(2)

mRNA	Protein	Name
NM_001185080.2	NP_001172009.1	claudin-15
NM_014343.3	NP_055158.1	claudin-15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables paracellular tight junction channel activity	IDA IDA: Inferred from direct assay	31188544	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in paracellular transport	IDA IDA: Inferred from direct assay	31188544	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in tight junction	IDA IDA: Inferred from direct assay	31188544	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN15 Protein Structure

PMP22_Claudin

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

claudin-15

Related Diseases

Diseases

Alias

Collagenous Colitis

Colitis, Collagenous

Microscopic Colitis, Collagenous Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02766	CLDN15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLDN15	VGNC	VGNC:80863
Mus musculus	CLDN15	MGD	MGI:1913103
Bos taurus	CLDN15	VGNC	VGNC:27405
Rattus norvegicus	CLDN15	RGD	RGD:1310678
Felis catus	CLDN15	VGNC	VGNC:80559

Name
Email *

	Sorry, but the email address you supplied was invalid.