Drd1 - dopamine receptor D1 Gene

Rattus norvegicus

Also known as D1a; Drd-1; Drd1a

Gene ID: 24316 | Gene type: protein coding

About Drd1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,440,036-175,444,182 (from NCBI)

This gene has 1 transcript (splice variant), 262 orthologues and 25 paralogues.

Summary

Enables several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and Enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and response to alkaloid. Located in several cellular components, including caveola; dendrite; and neuronal cell body. Is integral component of membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinson's disease; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; hyperglycemia; neurodegenerative disease (multiple); tracheal stenosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (Dopamine Receptor D1). [provided by Alliance of Genome Resources, Apr 2022]

Drd1 Products(3)

mRNA	Protein	Name
NM_012546.3	NP_036678.3	D(1A) dopamine receptor
XM_006253599.4	XP_006253661.1	D(1A) dopamine receptor isoform X1
XM_006253600.4	XP_006253662.1	D(1A) dopamine receptor isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	20623535	RGD
enables D3 dopamine receptor binding	IPI IPI: Inferred from physical interaction	14732731	RGD
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	11818555	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	15798088	RGD
enables angiotensin receptor binding	IPI IPI: Inferred from physical interaction	22193384	RGD
enables dopamine binding	IMP IMP: Inferred from mutant phenotype	27483345	RGD
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA IDA: Inferred from direct assay	11818555	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	16855100	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12122054	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23328768	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22843680	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12408866	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	8702641	RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in associative learning	IEP IEP: Inferred from expression pattern	23437091	RGD
involved in associative learning	IMP IMP: Inferred from mutant phenotype	15245880	RGD
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	16377433	RGD
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	14983054	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20969567	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	12707290	RGD
involved in eating behavior	IDA IDA: Inferred from direct assay	12944496	RGD
involved in grooming behavior	IDA IDA: Inferred from direct assay	12944496	RGD
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16641250	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	16377433	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	27638511	RGD
involved in negative regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	12944496	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	17314300	RGD
involved in operant conditioning	IMP IMP: Inferred from mutant phenotype	15245880	RGD
involved in orbitofrontal cortex development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in positive regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	11705777	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	20377617	RGD
involved in positive regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	18662324	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	26277342	RGD
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	15175382	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15175382	RGD
involved in regulation of monoatomic ion transport	IDA IDA: Inferred from direct assay	14983054	RGD
involved in regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15778266	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19759268	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17052844	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	19145071	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	20534718	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23873704	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	20875839	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	23447334	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20673846	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	15939542	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	18809391	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15798088	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21557291	RGD
involved in striatum development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in synapse assembly	IEP IEP: Inferred from expression pattern	10051231	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17576511	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	17576511	RGD
located in caveola	IDA IDA: Inferred from direct assay	15265765	RGD
located in cell surface	IDA IDA: Inferred from direct assay	27483345	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16641250	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	16228995	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11818555	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	21809413	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	21809413	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18340460	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17576511	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18424554	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd1 Protein Structure

7tm_1

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

D(1A) dopamine receptor

Dopamine-1A receptor

dopamine receptor D1A

Related Diseases

Diseases

Alias

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Bestiality

Zoophilia

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Drug Dependence

Cocaine Dependence

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Cvid9	Immunodeficiency, Common Variable, 9, Formerly
Cvid9, Formerly	Autoimmune Lymphoproliferative Syndrome Type Iii
Common Variable Immunodeficiency 9	Autoimmune Lymphoproliferative Syndrome 3
Immunodeficiency, Common Variable, 9	Type 3 Autoimmune Lymphoproliferative Syndrome
Immunodeficiency, Variable, Common, Type 9

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Cocaine Abuse

Cocaine-Related Disorders

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Heroin Dependence

Oppositional Defiant Disorder

Disorder	Oppositional Defiance
Behavioural Disorder	Oppositional Defiance
Disruptive Mood Dysregulation Disorder

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against	Alcohol Dependence, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Opiate Dependence

Opioid Dependence	Opioid Addiction
Opiate Addiction	Opioid Type Dependence
Opioid-Related Disorders	Opium Dependence
Narcotic Dependence	Intravenous Narcotism
Narcotism Nos	Oral Narcotism Nos

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Trichothiodystrophy 7, Nonphotosensitive

TTD7	Nonphotosensitive Trichothiodystrophy 7
Trichothiodystrophy 7, Non-Photosensitive

Pathological Gambling

Compulsive Gambling	Gambling
Gambling, Pathological	Addiction
Betting	Addiction
Gambling	Betting
Pathological	Gambling
Dependence

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Choreatic Disease

Chorea

Hereditary Chorea

Tic Disorder

Tics	Behavioral Tic

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Substance Dependence

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3

Cerebral Meningioma

Meningioma Of Cerebrum

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03994	DRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03995	Drd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03996	Drd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd1	NCBI	NCBI:1812