2. Gene
  3. Edn1 - endothelin 1 Gene

Edn1 - endothelin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Et1

Gene ID: 24323 | Gene type: protein coding

About Edn1

Primary_assembly 17: 22,454,420-22,460,885 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 131 orthologues, 2 paralogues and is associated with 122 phenotypes. Biased expression in Lung (RPKM 116.5), Uterus (RPKM 28.1) and 6 other tissues.

Summary

Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1). [provided by Alliance of Genome Resources, Apr 2022]

Edn1 Products(1)

mRNA Protein Name
NM_012548.2 NP_036680.1 endothelin-1 preproprotein

Edn1 Protein Structure

Endothelin

Endothelin: pfam00322 (48 - 76)

END

END: smart00272 (108 - 129)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

endothelin-1

ET-1

PPET1

preproendothelin-1

Recombinant Edn1 Proteins

Cat. No. Product Name Accession Purity
HY-P71446 Endothelin-1/EDN1 Protein, Rat (His-KSI) P22388 (C53-W73) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04162 EDN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04163 Edn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edn1 NCBI NCBI:1906