Grm4 - glutamate metabotropic receptor 4 Gene

Rattus norvegicus

Also known as mGluR4

Gene ID: 24417 | Gene type: protein coding

About Grm4

Primary_assembly 20: 5,481,124-5,572,821 reverse strand.mRatBN7.2:CM026993.1

This gene has 4 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 3 phenotypes. Restricted expression toward (RPKM 46.3).

Summary

Enables calcium-dependent protein binding activity and Calmodulin binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and positive regulation of MAPK cascade. Predicted to act upstream of or within chemical synaptic transmission and learning. Located in dendritic shaft; presynaptic active zone membrane; and terminal bouton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Grm4 Products(1)

mRNA	Protein	Name
NM_022666.2	NP_073157.2	metabotropic glutamate receptor 4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	21855531	RGD
enables calmodulin binding	IPI IPI: Inferred from physical interaction	21855531	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19822743	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic shaft	IDA IDA: Inferred from direct assay	11906782	RGD
located in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	11906782	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	11906782	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm4 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR4

0
200
400
600
800
912 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 4

glutamate receptor, metabotropic 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05828	GRM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05829	Grm4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05830	Grm4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm4	NCBI	NCBI:2914

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