Grm6 - glutamate metabotropic receptor 6 Gene

Rattus norvegicus

Also known as mGluR6

Gene ID: 24419 | Gene type: protein coding

About Grm6

Primary_assembly 10: 35,167,985-35,182,717 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 250 orthologues, 7 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 2.1), Testes (RPKM .8) and 6 other tissues.

Summary

Enables Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway and chemical synaptic transmission. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and new growing cell tip. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Grm6 Products(1)

mRNA	Protein	Name
NM_022920.2	NP_075209.1	metabotropic glutamate receptor 6 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IDA IDA: Inferred from direct assay	8389366	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	8389366	RGD
involved in chemical synaptic transmission	IEP IEP: Inferred from expression pattern	8389366	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm6 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tm_GPCRs

0
200
400
600
800
871 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 6

glutamate receptor, metabotropic 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05834	GRM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05835	Grm6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05836	Grm6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm6	NCBI	NCBI:2916

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