Il6r - interleukin 6 receptor Gene

Rattus norvegicus

Also known as IL6R1; Il6ra

Gene ID: 24499 | Gene type: protein coding

About Il6r

Summary

Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach Cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il6r Products(1)

mRNA	Protein	Name
NM_017020.3	NP_058716.2	interleukin-6 receptor subunit alpha precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in developmental growth	IMP IMP: Inferred from mutant phenotype	23855552	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19961020	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	7814800	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15084893	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	14751512	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	7814800	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	7814800	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	11171594	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11448096	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	8921254	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-6 receptor subunit alpha

IL-6 receptor subunit alpha	IL-6R 1
IL-6R subunit alpha	IL-6R-alpha
IL-6RA	interleukin 6 receptor, alpha

Recombinant Il6r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73224	IL-6R Protein, Rat (HEK293, His)	NP_058716.2 (L20-P364)	≥95%
HY-P73876	IL-6R Protein, Rat (HEK293, Fc)	NP_058716.2 (L20-P364)	≥95%

Related Agents

Approval

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9917	Tocilizumab	Antagonist	99.67%	Unkown
HY-P9916	Sarilumab	Inhibitor	98.37%	Unkown

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99702	Levilimab	Inhibitor	/	Phase 3
HY-P99385	Vobarilizumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10284	S7	Antagonist	99.12%	Unkown
HY-RS06777	IL6R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il6r	NCBI	NCBI:3570
Mus musculus	Il6r	NCBI

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