2. Immunology/Inflammation
  3. Interleukin Related
  4. S7

S7 is an IL-6 receptor antagonist and inhibits the binding between IL-6 and IL-6R. S7 can inhibit angiogenesis and tumor growth.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

S7 Chemical Structure

S7 Chemical Structure

CAS No. : 853248-13-2

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Based on 1 publication(s) in Google Scholar

S7 Related Antibodies

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View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

S7 is an IL-6 receptor antagonist and inhibits the binding between IL-6 and IL-6R. S7 can inhibit angiogenesis and tumor growth[1].

IC50 & Target[1]

IL-6

 

Molecular Weight

815.01

Formula

C37H70N10O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Leu-Ser-Leu-Ile-Thr-Arg-Leu
Sequence Shortening

LSLITRL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (61.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2270 mL 6.1349 mL 12.2698 mL
5 mM 0.2454 mL 1.2270 mL 2.4540 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2270 mL 6.1349 mL 12.2698 mL 30.6745 mL
5 mM 0.2454 mL 1.2270 mL 2.4540 mL 6.1349 mL
10 mM 0.1227 mL 0.6135 mL 1.2270 mL 3.0674 mL
15 mM 0.0818 mL 0.4090 mL 0.8180 mL 2.0450 mL
20 mM 0.0613 mL 0.3067 mL 0.6135 mL 1.5337 mL
25 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2270 mL
30 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0225 mL
40 mM 0.0307 mL 0.1534 mL 0.3067 mL 0.7669 mL
50 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6135 mL
60 mM 0.0204 mL 0.1022 mL 0.2045 mL 0.5112 mL
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S7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S7853248-13-2S 7S-7Interleukin RelatedILangiogenesistumorInhibitorinhibitorinhibit

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