NOS2 - nitric oxide synthase 2 Gene

Rattus norvegicus

Also known as iNos; Nos2a

Gene ID: 24599 | Gene type: protein coding

About NOS2

Primary_assembly 10: 63,815,308-63,851,210 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 152 phenotypes. Biased expression in Adrenal (RPKM 16.6), Heart (RPKM 1.1) and 5 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and Enzyme binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; cellular response to cytokine stimulus; and response to bacterium. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

NOS2 Products(1)

mRNA	Protein	Name
NM_012611.3	NP_036743.3	nitric oxide synthase, inducible

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	15475520	RGD
enables actin binding	IDA IDA: Inferred from direct assay	15858215	RGD
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	15858215	RGD
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	12107056	RGD
enables cadherin binding	IPI IPI: Inferred from physical interaction	15858215	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16172396	RGD
enables nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	11788371	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	15858215	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21464294	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17293490	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA IDA: Inferred from direct assay	12107056	RGD
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15800493	RGD
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12107056	RGD
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	22001142	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21975807	RGD
involved in cellular response to lithium ion	IEP IEP: Inferred from expression pattern	21994254	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cellular response to redox state	IEP IEP: Inferred from expression pattern	21964032	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21965676	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	18534083	RGD
involved in defense response to Gram-negative bacterium	IEP IEP: Inferred from expression pattern	16865779	RGD
involved in endothelial cell proliferation	IEP IEP: Inferred from expression pattern	15800493	RGD
involved in glycoside metabolic process	IEP IEP: Inferred from expression pattern	22006678	RGD
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	15001568	RGD
involved in nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	12826065	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12208351	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	12959638	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	12009427	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	21986892	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17919391	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	10997722	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	9001735	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	21107779	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	21986672	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9686345	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19329460	RGD
involved in response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	10997722	RGD
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	19802525	RGD
involved in retinoic acid receptor signaling pathway	IEP IEP: Inferred from expression pattern	15602748	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11943139	RGD
located in cytosol	IDA IDA: Inferred from direct assay	12085352	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	22019508	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11943139	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17293490	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	12085352	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOS2 Protein Structure

NOS_oxygenase_euk

Flavodoxin_1

FNR_like

0
200
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600
800
1000
1147 a.a.

Protein Preferred Names

Protein Names

nitric oxide synthase, inducible

NOS type II	inducible NO synthase
inducible NOS	inducible nitric oxide synthase
nitric oxide synthase 2, inducible, macrophage	nitric oxide synthase, inducible-like
peptidyl-cysteine S-nitrosylase NOS2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18732A	L-NMMA acetate	Inhibitor	≥99.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12124	BBS-4	Inhibitor	99.51%	Unkown
HY-RS09438	Nos2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-RS09437	NOS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09439	NOS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	NOS2	NCBI	NCBI:4843

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