Prkca - protein kinase C, alpha Gene

Rattus norvegicus

Also known as Pkca

Gene ID: 24680 | Gene type: protein coding

About Prkca

Primary_assembly 10: 92,894,012-93,288,012 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 26 phenotypes. Biased expression in Muscle (RPKM 146.), Brain (RPKM 14.7) and 9 other tissues.

Summary

Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca Products(1)

mRNA	Protein	Name
NM_001399299.1	NP_001386228.1	protein kinase C alpha type

Prkca Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

PKc_like

0
200
400
600
722 a.a.

Protein Preferred Names

Protein Names

protein kinase C alpha type

PKC-A

PKC-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11116	PRKCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11117	Prkca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11118	Prkca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkca	NCBI	NCBI:5578

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