Prkca - protein kinase C, alpha Gene

Rattus norvegicus

Also known as Pkca

Gene ID: 24680 | Gene type: protein coding

About Prkca

Primary_assembly 10: 92,894,012-93,288,012 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 26 phenotypes. Biased expression in Muscle (RPKM 146.), Brain (RPKM 14.7) and 9 other tissues.

Summary

Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca Products(1)

mRNA	Protein	Name
NM_001399299.1	NP_001386228.1	protein kinase C alpha type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9046017	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9514928	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15272003	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	18062921	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11562372	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18073185	RGD
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	16556598	RGD
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	16717194	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11864993	RGD
involved in positive regulation of cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	11864993	RGD
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	17408632	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17908462	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	18073185	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18972403	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9705215	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	17873323	RGD
involved in response to estradiol	IMP IMP: Inferred from mutant phenotype	18166159	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	17408632	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17487266	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17845534	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17640386	RGD
involved in response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	15272003	RGD
involved in response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	17905752	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	17728094	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11864993	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11864993	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11007882	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkca Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

PKc_like

0
200
400
600
722 a.a.

Protein Preferred Names

Protein Names

protein kinase C alpha type

PKC-A

PKC-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11116	PRKCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11117	Prkca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11118	Prkca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkca	NCBI	NCBI:5578

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