Sparc - secreted protein acidic and cysteine rich Gene

Rattus norvegicus

Gene ID: 24791 | Gene type: protein coding

About Sparc

Summary

Enables calcium ion binding activity. Involved in several processes, including animal organ development; response to L-ascorbic acid; and response to lead ion. Located in several cellular components, including extracellular space; nucleus; and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sparc Products(1)

mRNA	Protein	Name
NM_012656.2	NP_036788.1	SPARC precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	2322281	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in heart development	IEP IEP: Inferred from expression pattern	8287436	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	11335086	RGD
involved in lung development	IMP IMP: Inferred from mutant phenotype	7654384	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	12365801	RGD
involved in regulation of synapse organization	EXP EXP: Inferred from Experiment	21788491	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	21788491	RGD
involved in response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	9495521	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	10703670	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	9232954	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	11897705	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	10703670	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11371715	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	9232954	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	17384275	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	1412468	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	10703670	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	15779007	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2322281	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	21788491	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21788491	RGD
is active in synapse	EXP EXP: Inferred from Experiment	16507876	RGD
is active in synapse	IDA IDA: Inferred from direct assay	16507876	RGD
located in vesicle	IDA IDA: Inferred from direct assay	18758911	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SPARC

BM-40	ON
Secreted acidic cystein-rich glycoprotein (osteonectin)	basement-membrane protein 40
osteonectin	secreted acidic cysteine rich glycoprotein
secreted protein acidic and rich in cysteine	secreted protein, acidic, cysteine-rich (osteonectin)

Recombinant Sparc Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73420	SPARC Protein, Rat (HEK293, His)	P16975 (A18-I301)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13631	SPARC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sparc	NCBI	NCBI:6678
Macaca fascicularis	Sparc	NCBI	NCBI:101925878
Mus musculus	Sparc	NCBI	NCBI:20692

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