Tacr3 - tachykinin receptor 3 Gene

Rattus norvegicus

Also known as Nkr; Nmkr; Tac3r

Gene ID: 24808 | Gene type: protein coding

About Tacr3

Primary_assembly 2: 223,266,536-223,363,791 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 258 orthologues, 50 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 3.9), Kidney (RPKM 7.7) and 4 other tissues.

Summary

Enables tachykinin receptor activity. Involved in several processes, including hyperosmotic salinity response; positive regulation of uterine smooth muscle contraction; and response to alkaloid. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and nucleus. Used to study hypertension. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tacr3 Products(1)

mRNA	Protein	Name
NM_017053.1	NP_058749.1	neuromedin-K receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tachykinin receptor activity	IDA IDA: Inferred from direct assay	1662278	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	2478257	RGD
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	2471579	RGD
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	12390879	RGD
involved in regulation of dopamine metabolic process	IDA IDA: Inferred from direct assay	8574643	RGD
involved in regulation of feeding behavior	IDA IDA: Inferred from direct assay	2462199	RGD
involved in response to cocaine	IMP IMP: Inferred from mutant phenotype	17445241	RGD
involved in response to estradiol	IDA IDA: Inferred from direct assay	12390879	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10342838	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite membrane	IDA IDA: Inferred from direct assay	16357093	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	16357093	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr3 Protein Structure

7tmA_NKR_NK3R

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

neuromedin-K receptor

NK-3 receptor	NK-3R
Neuromedin K receptor (Neurokinin B/Tachikin 3)	neurokinin B receptor
tachikin receptor 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14149	TACR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14150	Tacr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14151	Tacr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tacr3	NCBI	NCBI:6870

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