1. Gene
  2. Tbxa2r - thromboxane A2 receptor Gene

Tbxa2r - thromboxane A2 receptor Gene

Rattus norvegicus
Gene ID: 24816 | Gene type: protein coding

About Tbxa2r

Primary_assembly 7: 8,383,378-8,388,176 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Thymus (RPKM 14.9), Lung (RPKM 32.5) and 7 other tissues.

Summary

Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tbxa2r Products(1)

mRNA Protein Name
NM_017054.2 NP_058750.2 thromboxane A2 receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20959415 RGD
enables thromboxane receptor activity IDA
IDA: Inferred from direct assay
7635958 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
10513923 RGD
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
16720756 RGD
involved in positive regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
7848332 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
16115588 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
7635958 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
10513923 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9262373 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
14621185 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
8092292 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11409645 RGD
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
7649122 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tbxa2r Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (24 - 316)

7tm_GPCRs

7tm_GPCRs: cd14964 (26 - 50)

7tm_GPCRs

7tm_GPCRs: cd14964 (62 - 84)

7tm_GPCRs

7tm_GPCRs: cd14964 (104 - 126)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (190 - 213)

7tm_GPCRs

7tm_GPCRs: cd14964 (240 - 262)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

thromboxane A2 receptor

TXA2-R

TXR2

Thromboxane receptor

prostanoid TP receptor

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbxa2r NCBI NCBI:6915