Tp53 - tumor protein p53 Gene

Rattus norvegicus

Also known as p53; Trp53

Gene ID: 24842 | Gene type: protein coding

About Tp53

Primary_assembly 10: 54,300,048-54,311,524 forward strand.mRatBN7.2:CM026983.1

This gene has 8 transcripts (splice variants), 251 orthologues, 2 paralogues and is associated with 253 phenotypes. Biased expression in Spleen (RPKM 12.5), Thymus (RPKM 11.3) and 9 other tissues.

Summary

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, Jul 2008]

Tp53 Products(1)

mRNA	Protein	Name
NM_030989.3	NP_112251.2	cellular tumor antigen p53

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	23941874	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10329733	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8389468	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15632413	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	21792911	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	27013579	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16330492	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17998337	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	11295070	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17289031	RGD
involved in cellular response to polyamine macromolecule	IEP IEP: Inferred from expression pattern	11502571	RGD
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	24817286	RGD
involved in cellular response to triglyceride	IEP IEP: Inferred from expression pattern	27013579	RGD
involved in negative regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	11502571	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8389468	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28834365	RGD
acts upstream of negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	30514107	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17659301	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16688778	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	18026139	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23164821	RGD
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	18317410	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11278372	RGD
acts upstream of regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	30514107	RGD
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	16688778	RGD
involved in response to UV	IEP IEP: Inferred from expression pattern	17724205	RGD
involved in response to UV-B	IEP IEP: Inferred from expression pattern	22559303	RGD
involved in response to X-ray	IEP IEP: Inferred from expression pattern	17699727	RGD
involved in response to X-ray	IMP IMP: Inferred from mutant phenotype	28834365	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17542038	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	16544096	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17651018	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20961644	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	18337831	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	17466256	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18093815	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	17600529	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	17962954	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	17516866	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18336558	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28834365	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	17289031	RGD
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	10329733	RGD
located in chromatin	IDA IDA: Inferred from direct assay	15632413	RGD
located in nucleus	IDA IDA: Inferred from direct assay	17571083	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15632413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tp53 Protein Structure

P53_TAD

P53

P53_tetramer

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

cellular tumor antigen p53

transformation related protein 53	tumor protein p53 (Li-Fraumeni syndrome)
tumor suppressor p53

Recombinant Tp53 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71703	p53 Protein, Rat (His)	P10361 (1M-391D)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19980	Eprenetapopt		99.52%	Phase 3
HY-16271	Kevetrin hydrochloride		≥98.0%	Phase 2
HY-P4210	Sulanemadlin	Inhibitor	96.21%	Phase 2

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10029	Nutlin-3a		99.00%	Unkown
HY-P1925A	GO-203 TFA		99.28%	Unkown
HY-148409	MMRi62		99.58%	Unkown
HY-19980A	PRIMA-1		≥98.0%	Unkown
HY-15898	Y-320		99.74%	Unkown
HY-158039	YCH2823		99.87%	Unkown
HY-W013053	Dibenz[a,h]anthracene	Inducer	≥98.0%	Unkown
HY-RS14912	TP53 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124036	DS-7423	Inhibitor	99.75%	Unkown
HY-100765	BI-0252		/	Unkown
HY-150620	BI-0282	Inhibitor	/	Unkown
HY-RS14913	Tp53 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14914	TP53AIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14915	TP53BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14916	TP53BP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14917	TP53I11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14918	TP53I13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14919	TP53I3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14920	TP53INP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14921	TP53INP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14922	TP53RK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-10029A	(Rac)-Nutlin-3		/	Unkown
HY-164544	USP7-055	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tp53	NCBI	NCBI:7157

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