Slc6a3 - solute carrier family 6 member 3 Gene

Rattus norvegicus

Also known as Dat1

Gene ID: 24898 | Gene type: protein coding

About Slc6a3

Primary_assembly 1: 29,709,443-29,750,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 31 phenotypes. Biased expression in Brain (RPKM 15.2), Kidney (RPKM .8) and 1 other tissue.

Summary

Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and Enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products(1)

mRNA	Protein	Name
NM_012694.2	NP_036826.1	sodium-dependent dopamine transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine binding	IDA IDA: Inferred from direct assay	15763134	RGD
enables amine binding	IPI IPI: Inferred from physical interaction	15763134	RGD
enables dopamine:sodium symporter activity	IDA IDA: Inferred from direct assay	1765147	RGD
enables dopamine:sodium symporter activity	IMP IMP: Inferred from mutant phenotype	1502198	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	15763134	RGD
enables norepinephrine:sodium symporter activity	IDA IDA: Inferred from direct assay	8125921	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	19419578	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	20035724	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15056723	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18256931	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dopamine transport	IDA IDA: Inferred from direct assay	1765147	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	15234104	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	15897718	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	12672939	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	15157990	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12541010	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15992364	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	8551328	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	32963038	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21399631	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	8551328	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	8551328	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a3 Protein Structure

SLC6sbd_DAT1

0
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300
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500
619 a.a.

Protein Preferred Names

Protein Names

sodium-dependent dopamine transporter

DA transporter	DAT
solute carrier family 6 (neurotransmitter transporter), member 3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13308	SLC6A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13309	Slc6a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13310	Slc6a3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a3	NCBI	NCBI:6531

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