Tacr2 - tachykinin receptor 2 Gene

Rattus norvegicus

Also known as Tac2r

Gene ID: 25007 | Gene type: protein coding

About Tacr2

Primary_assembly 20: 30,208,907-30,223,446 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 200 orthologues, 50 paralogues and is associated with 6 phenotypes. Biased expression in Adrenal (RPKM 43.), Uterus (RPKM 5.5) and 1 other tissue.

Summary

Enables substance K receptor activity. Involved in several processes, including operant conditioning; positive regulation of uterine smooth muscle contraction; and regulation of secretion by cell. Located in membrane. Used to study colitis and pulmonary hypertension. Biomarker of colitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tacr2 Products(1)

mRNA	Protein	Name
NM_080768.1	NP_542946.1	substance-K receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables substance K receptor activity	IDA IDA: Inferred from direct assay	1662278	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	11275010	RGD
involved in negative regulation of luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	9376629	RGD
involved in operant conditioning	IMP IMP: Inferred from mutant phenotype	17324063	RGD
involved in positive regulation of acetylcholine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	12747940	RGD
involved in positive regulation of monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	11275010	RGD
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	12390879	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	9374705	RGD
involved in prolactin secretion	IMP IMP: Inferred from mutant phenotype	9376629	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	18440496	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr2 Protein Structure

7tmA_SKR_NK2R

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

substance-K receptor

NK-2 receptor	NK-2R
SKR	Tachykinin 2 (substance K) receptor
neurokinin A receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3848	Tyr0-Neurokinin A	Agonist	/	Unkown
HY-RS14146	TACR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14147	Tacr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14148	Tacr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tacr2	NCBI	NCBI:6865

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