Acat1 - acetyl-CoA acetyltransferase 1 Gene

Rattus norvegicus

Also known as RATACAL

Gene ID: 25014 | Gene type: protein coding

About Acat1

Primary_assembly 8: 53,979,813-54,008,855 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 1952.7), Kidney (RPKM 13.6) and 9 other tissues.

Summary

Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; response to hormone; and response to starvation. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acat1 Products(2)

mRNA	Protein	Name
NM_017075.2	NP_058771.2	acetyl-CoA acetyltransferase, mitochondrial precursor
NM_017075.2	NP_058771.2	acetyl-CoA acetyltransferase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyl-CoA C-acetyltransferase activity	IDA IDA: Inferred from direct assay	2478525	RGD
enables coenzyme A binding	IPI IPI: Inferred from physical interaction	1672610	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	1684101	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11988101	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adipose tissue development	IEP IEP: Inferred from expression pattern	2866764	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	5166591	RGD
involved in metanephric proximal convoluted tubule development	IEP IEP: Inferred from expression pattern	7733320	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	6144148	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	6489337	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	2985752	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	11988101	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	17180682	RGD
NOT located in peroxisome	IDA IDA: Inferred from direct assay	17180682	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acat1 Protein Structure

thiolase

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

acetyl-CoA acetyltransferase, mitochondrial

acetoacetyl-CoA thiolase	acetyl-Co A acetyltransferase 1 mitochondrial
acetyl-coenzyme A acetyltransferase 1

Related Agents

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13215	Avasimibe	Inhibitor	99.85%	Phase 3
HY-100401A	Pactimibe sulfate	Inhibitor	≥98.0%	Phase 3
HY-100401	Pactimibe	Inhibitor	99.98%	Phase 3
HY-100400A	K-604 dihydrochloride	Inhibitor	99.42%	Phase 2
HY-100399A	Nevanimibe hydrochloride	Inhibitor	99.92%	Phase 2
HY-100399	Nevanimibe	Inhibitor	/	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acat1	NCBI	NCBI:38

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