Slc16a1 - solute carrier family 16 member 1 Gene

Rattus norvegicus

Also known as MCT1; RNMCT1; RATMCT1

Gene ID: 25027 | Gene type: protein coding

About Slc16a1

Primary_assembly 2: 192,124,289-192,144,611 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 339 orthologues, 13 paralogues and is associated with 8 phenotypes. Biased expression in Heart (RPKM 11.1), Thymus (RPKM 589.2) and 9 other tissues.

Summary

Enables identical protein binding activity; monocarboxylic acid transmembrane transporter activity; and organic cyclic compound binding activity. Involved in cellular response to organic cyclic compound and plasma membrane lactate transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a1 Products(1)

mRNA	Protein	Name
NM_012716.2	NP_036848.1	monocarboxylate transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carboxylic acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10714609	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19473976	RGD
enables lactate:proton symporter activity	IDA IDA: Inferred from direct assay	9639576	RGD
enables monocarboxylic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	8526936	RGD
enables organic cyclic compound binding	IMP IMP: Inferred from mutant phenotype	19473976	RGD
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	19473976	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11719518	RGD
enables solute:proton symporter activity	IDA IDA: Inferred from direct assay	9374487	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in carboxylic acid transmembrane transport	IMP IMP: Inferred from mutant phenotype	10714609	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19473976	RGD
involved in cellular response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	19473976	RGD
involved in lactate transmembrane transport	IDA IDA: Inferred from direct assay	19473976	RGD
involved in lactate transmembrane transport	IMP IMP: Inferred from mutant phenotype	19473976	RGD
involved in monocarboxylic acid transport	IDA IDA: Inferred from direct assay	8526936	RGD
involved in plasma membrane lactate transport	IDA IDA: Inferred from direct assay	19929853	RGD
involved in plasma membrane lactate transport	IMP IMP: Inferred from mutant phenotype	17127621	RGD
involved in pyruvate transmembrane transport	IDA IDA: Inferred from direct assay	9639576	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18619525	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10564700	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11719518	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc16a1 Protein Structure

2A0113

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 1

MCT 1	solute carrier 16 (monocarboxylic acid transporter), member 1
solute carrier family 16 (monocarboxylate transporter), member 1	solute carrier family 16 (monocarboxylic acid transporters), member 1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13016	SLC16A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13017	Slc16a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13018	Slc16a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc16a1	NCBI	NCBI:6566

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