SLC16A1 - solute carrier family 16 member 1 Gene

Homo sapiens

Also known as MCT; HHF7; MCT1; MCT1D

Gene ID: 6566 | Gene type: protein coding

About SLC16A1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,911,847-112,956,196 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 339 orthologues, 13 paralogues and is associated with 6 phenotypes. Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues.

Summary

The protein encoded by this gene is a proton-linked Monocarboxylate Transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

SLC16A1 Products(3)

mRNA	Protein	Name
XM_047428789.1	XP_047284745.1	monocarboxylate transporter 1 isoform X1
NM_001166496.2	NP_001159968.1	monocarboxylate transporter 1
NM_003051.4	NP_003042.3	monocarboxylate transporter 1

SLC16A1 Protein Structure

MFS_1

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 1

MCT 1	solute carrier family 16 (monocarboxylate transporter), member 1
solute carrier family 16 (monocarboxylic acid transporters), member 1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Related Diseases

Diseases

Alias

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Diversion Colitis

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Hyperinsulinemic Hypoglycemia, Familial, 7

HHF7	Exercise-Induced Hyperinsulinemic Hypoglycemia
Exercise-Induced Hyperinsulinism	Familial Hyperinsulinemic Hypoglycemia 7
Eihi	Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency
Hyperinsulinism Due To Slc16a1 Deficiency	Hyperinsulinemic Hypoglycemia, Exercise-Induced
Exercise Induced Hyperinsulinemic Hypoglycemia	Hyperinsulinemic Hypoglycemia Exercise-Induced
Hyperinsulinemic Hypoglycemia Familial 7

Hyperinsulinism

Hyperinsulinemia

Monocarboxylate Transporter 1 Deficiency

Ketoacidosis Due To Monocarboxylate Transporter-1 Deficiency	MCT1D
Ketosis

Erythrocyte Lactate Transporter Defect

Metabolic Myopathy Due To Lactate Transporter Defect	Lactate Transporter Defect, Myopathy Due To
Symptomatic Deficiency In Lactate Transport	SDLT

Asphyxia Neonatorum

Birth Asphyxia	Postnatal Asphyxia
Asphyxia - Birth	Asphyxia, In Liveborn Infant
Hypoxia Neonatorum	Hypoxia, In Liveborn Infant
Intrapartum Asphyxia	Neonatal Asphyxia
Newborn Asphyxia	Asphyxia In Liveborn Infant
Asphyxia Of Newborn Nos	Perinatal Asphyxia
Perinatal Hypoxia	Newborn Asphyxiation

Biotin Deficiency

Biotin Deficiency Disease	B7 Deficiency
Biotan Vitamin Deficiency

Hyperinsulinemic Hypoglycemia, Familial, 6

Hyperinsulinism-Hyperammonemia Syndrome	HHF6
Familial Hyperinsulinemic Hypoglycemia 6	Hi/Ha Syndrome
Ha/Hi Syndrome	Hyperinsulinemic Hypoglycemia Familial 6
Hyperinsulinism Hyperammonemia Syndrome	Hhs

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13016	SLC16A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13017	Slc16a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13018	Slc16a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC16A1	VGNC	VGNC:46235
Macaca mulatta	SLC16A1	VGNC	VGNC:77395
Rattus norvegicus	SLC16A1	RGD	RGD:3690
Bos taurus	SLC16A1	VGNC	VGNC:34683
Mus musculus	SLC16A1	MGD	MGI:106013

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