Il4r - interleukin 4 receptor Gene

Rattus norvegicus

Also known as Il4ra

Gene ID: 25084 | Gene type: protein coding

About Il4r

Summary

Predicted to enable cytokine receptor activity. Involved in several processes, including ovulation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il4r Products(1)

mRNA	Protein	Name
NM_133380.2	NP_596871.2	interleukin-4 receptor subunit alpha precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10525162	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	17652031	RGD
involved in response to odorant	IEP IEP: Inferred from expression pattern	23103411	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10525162	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-4 receptor subunit alpha

IL-4 receptor subunit alpha	IL-4R subunit alpha
IL-4R-alpha	IL-4RA
interleukin 4 receptor, alpha	interleukin-4 receptor alpha chain

Recombinant Il4r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73217	IL-4R alpha/CD124 Protein, Rat (HEK293, His)	Q63257-1 (I26-R232)	≥95%
HY-P74801	IL-4R alpha/CD124 Protein, Rat (HEK293, Fc)	Q63257-1 (I26-R232)	≥95%

Related Agents

Approval

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9926	Dupilumab	Inhibitor	≥99.2%	Unkown
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990093	Stapokibart	Inhibitor	96.34%	Phase 3
HY-P990090	Rademikibart	Inhibitor	98.69%	Phase 3
HY-P99724	Manfidokimab		95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06769	IL4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990708	Bizaxofusp		/	Unkown
HY-P990910	Comekibart	Inhibitor	/	Unkown
HY-P991031	Telikibart	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il4r	NCBI	NCBI:3566
Macaca fascicularis	Il4r	NCBI	NCBI:102133649

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