1. Immunology/Inflammation
  2. Interleukin Related
  3. Dupilumab

Dupilumab  (Synonyms: REGN-668; SAR-231893)

Cat. No.: HY-P9926 Purity: ≥99.2%
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Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

For research use only. We do not sell to patients.

CAS No. : 1190264-60-8

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Dupilumab

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis[1].

Isotype

Human IgG4 kappa

Recommend Isotype Controls
Species

Human

IC50 & Target[1]

IL-2

 

IL-4

 

IL-13

 

In Vitro

Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, and TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, and S100A8 and trends for suppression (CXCL1 and S100A7) are found with 300 mg of Dupilumab[1].
Major suppressions of hyperplasia-related genes (eg, K16) and reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays and qRT-PCR. The changes in other critical epidermal alterations in severe atopic dermatitis (AD) skin are also measured, including significant increases in claudin and lipid product levels with 300 mg of Dupilumab. A trend of dose-dependent increases in expression of differentiation genes (LOR and FLG) is observed after adjusting for suppression of epidermal hyperplasia, as demonstrated by K16 reductions with Dupilumab[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

147000.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Dupilumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Flow cytometry analysis of Raji cells labelling IL-4Rα with Dupilumab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
Purity & Documentation

Purity: ≥99.2%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dupilumab
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HY-P9926
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