Avpr2 - arginine vasopressin receptor 2 Gene

Rattus norvegicus

Gene ID: 25108 | Gene type: protein coding

About Avpr2

Primary_assembly X: 151,633,522-151,635,989 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 233 orthologues, 16 paralogues and is associated with 20 phenotypes. Biased expression in Kidney (RPKM 45.6), Thymus (RPKM 4.9) and 7 other tissues.

Summary

Predicted to enable peptide binding activity and Vasopressin Receptor activity. Involved in several processes, including negative regulation of renal sodium excretion; negative regulation of urine volume; and positive regulation of systemic arterial blood pressure. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine Vasopressin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Avpr2 Products(1)

mRNA	Protein	Name
NM_019136.2	NP_062009.1	vasopressin V2 receptor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of urine volume	IMP IMP: Inferred from mutant phenotype	18057218	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	12072411	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18787031	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16352747	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	18957383	RGD
involved in telencephalon development	IEP IEP: Inferred from expression pattern	11021977	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Avpr2 Protein Structure

7tmA_V2R

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

vasopressin V2 receptor

AVPR V2	V2R
Vasopressin receptor V2	antidiuretic hormone receptor
renal-type arginine vasopressin receptor

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049A	Argipressin diacetate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01287	AVPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01288	Avpr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01289	Avpr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Avpr2	NCBI	NCBI:554

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