Stat5b - signal transducer and activator of transcription 5B Gene

Rattus norvegicus

Gene ID: 25126 | Gene type: protein coding

About Stat5b

Primary_assembly 10: 85,705,670-85,775,668 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 286 orthologues, 5 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues.

Summary

Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; luteinization; and receptor signaling pathway via JAK-STAT. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b Products(1)

mRNA	Protein	Name
NM_022380.2	NP_071775.1	signal transducer and activator of transcription 5B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11562369	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11064147	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16527988	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	20639532	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	11064147	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10720695	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11064147	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IDA IDA: Inferred from direct assay	17565389	RGD
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11064147	RGD
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	20639532	RGD
involved in liver development	IDA IDA: Inferred from direct assay	17565389	RGD
involved in luteinization	IDA IDA: Inferred from direct assay	10598581	RGD
involved in positive regulation of fibroblast growth factor production	IMP IMP: Inferred from mutant phenotype	16527988	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16527988	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	16527988	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16527988	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11562369	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12933671	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16730240	RGD
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	17327369	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	9092792	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	10224108	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11064147	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat5b Protein Structure

STAT_int

STAT5_CCD

STAT5_DBD

SH2_STAT5b

0
200
400
600
795 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 5B

Signal transducer and activator of transcription 5a

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148813	AK-2292		99.73%	Unkown
HY-136546	Stafia-1	Inhibitor	99.37%	Unkown
HY-112647	Stafib-1	Inhibitor	≥98.0%	Unkown
HY-19527	IST5-002		99.36%	Unkown
HY-112648	Stafib-2	Inhibitor	98.42%	Unkown
HY-112649	Pomstafib-2		99.37%	Unkown
HY-170837	STAT5-IN-3	Inhibitor	/	Unkown
HY-RS13893	STAT5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13894	Stat5b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13895	Stat5b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat5b	NCBI	NCBI:6777

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