2. Gene
  3. Esr2 - estrogen receptor 2 Gene

Esr2 - estrogen receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Erb2; ERbeta; ER-beta

Gene ID: 25149 | Gene type: protein coding

About Esr2

Primary_assembly 6: 94,809,547-94,908,919 reverse strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 277 orthologues, 8 paralogues and is associated with 103 phenotypes. Biased expression in Uterus (RPKM 6.7), Brain (RPKM 3.1) and 5 other tissues.

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (Estrogen Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Esr2 Products(1)

mRNA Protein Name
NM_012754.3 NP_036886.3 estrogen receptor beta

Esr2 Protein Structure

ERbeta_N

ERbeta_N: pfam12497 (34 - 143)

NR_DBD_ER

NR_DBD_ER: cd07171 (162 - 243)

NR_LBD_ER

NR_LBD_ER: cd06949 (281 - 534)

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  • 567 a.a.
Protein Preferred Names Protein Names

estrogen receptor beta

estrogen receptor 2 (ER beta)

estrogen receptor 2 beta

nuclear receptor subfamily 3 group A member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-169063 ZINC05925939 Inhibitor / Unkown
HY-RS04532 ESR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04533 Esr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04534 Esr2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr2 NCBI NCBI:2100