Esr2 - estrogen receptor 2 Gene

Rattus norvegicus

Also known as Erb2; ERbeta; ER-beta

Gene ID: 25149 | Gene type: protein coding

About Esr2

Primary_assembly 6: 94,809,547-94,908,919 reverse strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 277 orthologues, 8 paralogues and is associated with 103 phenotypes. Biased expression in Uterus (RPKM 6.7), Brain (RPKM 3.1) and 5 other tissues.

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (Estrogen Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Esr2 Products(1)

mRNA	Protein	Name
NM_012754.3	NP_036886.3	estrogen receptor beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12047722	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12047722	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	19683557	RGD
enables estradiol binding	IPI IPI: Inferred from physical interaction	9292936	RGD
enables estrogen binding	IPI IPI: Inferred from physical interaction	9048584	RGD
enables estrogen response element binding	IDA IDA: Inferred from direct assay	9600083	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	9048584	RGD
enables hormone binding	IDA IDA: Inferred from direct assay	17928626	RGD
enables hormone binding	IMP IMP: Inferred from mutant phenotype	15105439	RGD
enables hormone binding	IPI IPI: Inferred from physical interaction	9048584	RGD
enables nuclear steroid receptor activity	IDA IDA: Inferred from direct assay	17928626	RGD
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	9048584	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	20689342	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	24046281	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16020483	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12200235	RGD
enables steroid binding	IDA IDA: Inferred from direct assay	15705806	RGD
enables steroid hormone binding	IPI IPI: Inferred from physical interaction	9048584	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Sertoli cell development	IEP IEP: Inferred from expression pattern	24056172	RGD
involved in Sertoli cell proliferation	IMP IMP: Inferred from mutant phenotype	17928626	RGD
involved in amygdala development	IEP IEP: Inferred from expression pattern	22791648	RGD
involved in behavioral fear response	IDA IDA: Inferred from direct assay	15514081	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	17928626	RGD
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	21127968	RGD
involved in cellular response to magnetism	IEP IEP: Inferred from expression pattern	23469792	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	23596885	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19279558	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	16542644	RGD
involved in estrous cycle	IMP IMP: Inferred from mutant phenotype	11854469	RGD
involved in female gonad development	IEP IEP: Inferred from expression pattern	9927330	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	12960049	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	16904920	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	15944240	RGD
involved in negative regulation of behavior	IDA IDA: Inferred from direct assay	15514081	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	12370428	RGD
involved in negative regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	12119576	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15126114	RGD
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	23608653	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22099601	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9600083	RGD
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	17928626	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	17971845	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15564578	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17928626	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24440742	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	22025007	RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17928626	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12047722	RGD
involved in prostate gland development	IEP IEP: Inferred from expression pattern	9492016	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18516675	RGD
involved in response to bisphenol A	IEP IEP: Inferred from expression pattern	22957036	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	15087431	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19948032	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15667451	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23591044	RGD
involved in response to genistein	IEP IEP: Inferred from expression pattern	19230619	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	23591044	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	10342845	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	23943137	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	27602328	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	18596125	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	24070737	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	12764114	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	23500659	RGD
involved in response to testosterone	IMP IMP: Inferred from mutant phenotype	16904920	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20686183	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	24440742	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	15024130	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	23701910	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16122717	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17928626	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	10342845	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esr2 Protein Structure

ERbeta_N

NR_DBD_ER

NR_LBD_ER

0
100
200
300
400
500
567 a.a.

Protein Preferred Names

Protein Names

estrogen receptor beta

estrogen receptor 2 (ER beta)	estrogen receptor 2 beta
nuclear receptor subfamily 3 group A member 2

Esr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Esr2	Q62986	Rps27a	Rattus norvegicus	P62989	Anti Bait CoIP	21808025

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169063	ZINC05925939	Inhibitor	/	Unkown
HY-RS04532	ESR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04533	Esr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04534	Esr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esr2	NCBI	NCBI:2100

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