Pgr - progesterone receptor Gene

Rattus norvegicus

Gene ID: 25154 | Gene type: protein coding

About Pgr

Primary_assembly 8: 6,072,673-6,131,344 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 19 phenotypes. Biased expression in Uterus (RPKM 178.1), Brain (RPKM 36.9) and 1 other tissue.

Summary

Enables several functions, including sequence-specific DNA binding activity; steroid binding activity; and steroid hormone receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; estrous cycle; and regulation of transcription, DNA-templated. Located in several cellular components, including axon terminus; dendritic spine; and perikaryon. Biomarker of endometriosis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (Progesterone Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Pgr Products(1)

mRNA	Protein	Name
NM_022847.2	NP_074038.2	progesterone receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone binding	IMP IMP: Inferred from mutant phenotype	11113338	RGD
enables nuclear steroid receptor activity	IMP IMP: Inferred from mutant phenotype	11113338	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16020483	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17109827	RGD
enables steroid binding	IMP IMP: Inferred from mutant phenotype	11113338	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	8344215	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	8344215	RGD
involved in cellular response to luteinizing hormone stimulus	IEP IEP: Inferred from expression pattern	8344215	RGD
involved in cellular response to wortmannin	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in diterpenoid metabolic process	IEP IEP: Inferred from expression pattern	8344215	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	16461543	RGD
involved in female mating behavior	IMP IMP: Inferred from mutant phenotype	19094083	RGD
involved in luteinization	IEP IEP: Inferred from expression pattern	8344215	RGD
involved in negative regulation of DNA-templated transcription	IEP IEP: Inferred from expression pattern	12457039	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22778216	RGD
involved in negative regulation of granulosa cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19208546	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8344215	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16020483	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21440892	RGD
involved in response to cocaine	IDA IDA: Inferred from direct assay	17109827	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	22147012	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	22147012	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	18720413	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	18720413	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18720413	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	18720413	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	18720413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pgr Protein Structure

Prog_receptor

NR_DBD_GR_PR

NR_LBD_PR

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

progesterone receptor

PR	nuclear receptor subfamily 3 group C member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10396	PGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10397	Pgr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10398	Pgr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pgr	NCBI	NCBI:5241
Mus musculus	Pgr	NCBI	NCBI:18667

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