2. Gene
  3. Il6st - interleukin 6 cytokine family signal transducer Gene

Il6st - interleukin 6 cytokine family signal transducer Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gp130; Ac1055; Il-6rb

Gene ID: 25205 | Gene type: protein coding

About Il6st

Summary

Predicted to enable several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and scaffold protein binding activity. Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Located in neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st Products(1)

mRNA Protein Name
NM_001008725.3 NP_001008725.2 interleukin-6 receptor subunit beta precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in interleukin-6-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18280048 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
17437036 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17322172 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15371280 RGD
involved in triglyceride mobilization IMP
IMP: Inferred from mutant phenotype
8843746 RGD
Cellular Component GO Annotation Evidence Reference Source
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8921254 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-6 receptor subunit beta

IL-6 receptor subunit beta

IL-6R subunit beta

interleukin 6 signal transducer

membrane glycoprotein 130

oncostatin-M receptor subunit alpha

Recombinant Il6st Proteins

Cat. No. Product Name Accession Purity
HY-P76374 gp130/IL6ST Protein, Rat (HEK293, His) NP_001008725.2 (Q23-E618) ≥95%
HY-P76375 gp130/IL6ST Protein, Rat (HEK293, His-Fc) H9BFG4 (M4-E618) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06778 IL6ST Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6st NCBI NCBI:3572
Mus musculus Il6st NCBI NCBI:16195
Macaca mulatta Il6st NCBI NCBI:574127