2. Gene
  3. Il6st - interleukin 6 signal transducer Gene

Il6st - interleukin 6 signal transducer Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD130; gp130; D13Ertd699e; 5133400A03Rik

Gene ID: 16195 | Gene type: protein coding

About Il6st

Summary

Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach Cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st Products(1)

mRNA Protein Name
NM_010560.3 NP_034690.3 interleukin-6 receptor subunit beta precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to interleukin-11 binding IDA
IDA: Inferred from direct assay
7957045 MGI
contributes to interleukin-11 receptor activity IDA
IDA: Inferred from direct assay
7957045 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16452727 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
7957045 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
10205167 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
involved in intestinal epithelial cell development IDA
IDA: Inferred from direct assay
25731159 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
acts upstream of or within positive regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10486560 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15051883 MGI
acts upstream of or within regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
12629177 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12147685 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell body IDA
IDA: Inferred from direct assay
10989258 MGI
located in dendrite IDA
IDA: Inferred from direct assay
10989258 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11275690 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
10989258 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-6 receptor subunit beta

IL-6 receptor subunit beta

IL-6R subunit beta

IL-6R-beta

IL-6RB

membrane glycoprotein 130

oncostatin-M receptor subunit alpha

Recombinant Il6st Proteins

Cat. No. Product Name Accession Purity
HY-P76370 gp130/IL6ST Protein, Mouse (HEK293, Fc) Q00560/NP_034690 (Q23-E617) ≥95%
HY-P76371 gp130/IL6ST Protein, Mouse (HEK293, His) Q00560/NP_034690 (Q23-E617) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06778 IL6ST Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6st NCBI NCBI:3572
Rattus norvegicus Il6st NCBI NCBI:25205
Macaca mulatta Il6st NCBI NCBI:574127