Bdkrb2 - bradykinin receptor B2 Gene

Rattus norvegicus

Also known as B2BKR; B2BRA

Gene ID: 25245 | Gene type: protein coding

About Bdkrb2

Primary_assembly 6: 124,472,566-124,502,497 forward strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 362 orthologues, 8 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 44.5), Uterus (RPKM 44.) and 8 other tissues.

Summary

Enables beta-2 Adrenergic Receptor binding activity and Bradykinin Receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Located in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (Bradykinin Receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb2 Products(2)

mRNA	Protein	Name
NM_173100.3	NP_775123.2	B2 bradykinin receptor isoform 2
NM_001270713.2	NP_001257642.1	B2 bradykinin receptor isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-2 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	20150590	RGD
enables bradykinin receptor activity	IDA IDA: Inferred from direct assay	1715575	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12177051	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	7791078	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19565561	RGD
involved in maintenance of blood-brain barrier	IDA IDA: Inferred from direct assay	20080302	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16507603	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12177051	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15576455	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18190998	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bdkrb2 Protein Structure

7tmA_BK-2

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

B2 bradykinin receptor

B2R	BK-2 receptor
bradykinin receptor, beta 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01457	BDKRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01458	Bdkrb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01459	Bdkrb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bdkrb2	NCBI	NCBI:624

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