BDKRB2 - bradykinin receptor B2 Gene

Homo sapiens

Also known as B2R; BK2; BK-2; BKR2; BRB2

Gene ID: 624 | Gene type: protein coding

About BDKRB2

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,204,839-96,244,164 (from NCBI)

This gene has 3 transcripts (splice variants), 362 orthologues and 7 paralogues. Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues.

Summary

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]

BDKRB2 Products(2)

mRNA	Protein	Name
NM_001379692.1	NP_001366621.1	B2 bradykinin receptor
NM_000623.4	NP_000614.1	B2 bradykinin receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bradykinin receptor activity	IDA IDA: Inferred from direct assay	1314587	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	17077303	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18672896	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10993080	GOA
enables type 1 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	10993080	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate secretion	IDA IDA: Inferred from direct assay	17077303	GOA
involved in vasodilation	IDA IDA: Inferred from direct assay	4322742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	17077303	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17077303	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BDKRB2 Protein Structure

7tm_1

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

B2 bradykinin receptor

BK-2 receptor

BDKRB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BDKRB2	P30411	P01042-PRO_0000006688	Homo sapiens	P01042-PRO_0000006688	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

BDKRB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81722	BDKRB2 Antibody (YA1467)	WB, IP	Human, Mouse

Related Diseases

Diseases

Alias

Placenta Accreta

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Brucella Abortus Brucellosis

Brucellosis, Bovine

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Brain Edema

Intracranial Swelling	Wet Brain
Cerebral Edema

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

C1 Inhibitor Deficiency

Quincke Edema	Angioedemas, Hereditary
Angioedema

Acquired Angioedema

Acquired C1 Inhibitor Deficiency	Angioedema, Acquired
Aae	Acquired Angioneurotic Edema
Acquired Bradykinine-Induced Angioedema	Acquired Non Histamine-Induced Angioedema
Acquired Angioneurotic Oedema	Aae - [Acquired Angioneurotic Oedema]

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01457	BDKRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01458	Bdkrb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01459	Bdkrb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BDKRB2	RGD	RGD:2201
Bos taurus	BDKRB2	VGNC	VGNC:26460
Canis familiaris	BDKRB2	VGNC	VGNC:38425
Mus musculus	BDKRB2	MGD	MGI:102845

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