STXBP4 - syntaxin binding protein 4 Gene

Homo sapiens

Also known as Synip

Gene ID: 252983 | Gene type: protein coding

About STXBP4

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,968,765-55,213,273 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 1.4), thyroid (RPKM 1.4) and 25 other tissues.

Summary

Enables syntaxin binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

STXBP4 Products(4)

mRNA	Protein	Name
NM_001398481.1	NP_001385410.1	syntaxin-binding protein 4 isoform 2
NM_001398482.1	NP_001385411.1	syntaxin-binding protein 4 isoform 3
NM_001398483.1	NP_001385412.1	syntaxin-binding protein 4 isoform 4
NM_178509.6	NP_848604.3	syntaxin-binding protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19451233	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	12855681	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19451233	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	19451233	GOA
involved in positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	19451233	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19451233	GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	12855681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STXBP4 Protein Structure

PDZ

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

syntaxin-binding protein 4

STX4-interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13992	STXBP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STXBP4	RGD	RGD:1307903
Felis catus	STXBP4	VGNC	VGNC:99466
Bos taurus	STXBP4	VGNC	VGNC:106959
Mus musculus	STXBP4	MGD	MGI:1342296
Macaca mulatta	STXBP4	VGNC	VGNC:78173
Canis familiaris	STXBP4	VGNC	VGNC:46962

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