FUT8 - fucosyltransferase 8 Gene

Homo sapiens

Also known as CDGF; CDGF1

Gene ID: 2530 | Gene type: protein coding

About FUT8

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,356,842-65,744,121 (from NCBI)

This gene has 17 transcripts (splice variants), 267 orthologues and is associated with 2 phenotypes. Ubiquitous expression in stomach (RPKM 6.3), brain (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes an Enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This Enzyme is distinct from Other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of Cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

FUT8 Products(6)

mRNA	Protein	Name
NM_001371533.1	NP_001358462.1	alpha-(1,6)-fucosyltransferase isoform a
NM_001371534.1	NP_001358463.1	alpha-(1,6)-fucosyltransferase isoform a
NM_001371536.1	NP_001358465.1	alpha-(1,6)-fucosyltransferase isoform c
NM_004480.4	NP_004471.4	alpha-(1,6)-fucosyltransferase isoform b
NM_178155.3	NP_835368.1	alpha-(1,6)-fucosyltransferase isoform a
NM_178156.2	NP_835369.1	alpha-(1,6)-fucosyltransferase isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycoprotein 6-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	17172260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GDP-L-fucose metabolic process	IDA IDA: Inferred from direct assay	17172260	GOA
involved in protein N-linked glycosylation via asparagine	IDA IDA: Inferred from direct assay	17172260	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT8 Protein Structure

SH3_9

0
100
200
300
400
500
575 a.a.

Protein Preferred Names

Protein Names

alpha-(1,6)-fucosyltransferase

GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase

FUT8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FUT8	Q9BYC5	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
Intra	FUT8	Q9BYC5	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FUT8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75181	FUT8 Protein, Human (sf9, His)	Q9BYC5-1 (R68-K575)	≥95%

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation With Defective Fucosylation 1

CDGF1

Cdgf

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155747	FDW028	Inhibitor	99.51%	Unkown
HY-E70157	Fucosyltransferase 8		/	Unkown
HY-RS05159	FUT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99010A	Bemarituzumab (FUT8-KO)	Inhibitor	/	Unkown
HY-P9977A	Amivantamab (FUT8-KO)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FUT8	VGNC	VGNC:41015
Bos taurus	FUT8	VGNC	VGNC:29152
Macaca mulatta	FUT8	VGNC	VGNC:72829
Rattus norvegicus	FUT8	RGD	RGD:1303096
Mus musculus	FUT8	MGD	MGI:1858901
Felis catus	FUT8	VGNC	VGNC:62394
Others	FUT8	NCBI

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