Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Rattus norvegicus

Gene ID: 25332 | Gene type: protein coding

About Mgmt

Primary_assembly 1: 191,710,930-191,937,756 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 189 orthologues and is associated with 31 phenotypes. Biased expression in Liver (RPKM 16.5), Spleen (RPKM 119.4) and 9 other tissues.

Summary

Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Located in nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products(2)

mRNA	Protein	Name
NM_012861.1	NP_036993.1	methylated-DNA--protein-cysteine methyltransferase
NM_012861.1	NP_036993.1	methylated-DNA--protein-cysteine methyltransferase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12479403	RGD
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity	IDA IDA: Inferred from direct assay	15025514	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	15025514	RGD
involved in DNA damage response	IEP IEP: Inferred from expression pattern	12815001	RGD
involved in cellular response to ionizing radiation	IEP IEP: Inferred from expression pattern	9780001	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19549930	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	11133343	RGD
involved in mammary gland epithelial cell differentiation	IEP IEP: Inferred from expression pattern	16086375	RGD
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	1945835	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11524300	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	20051376	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12517412	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20011461	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19860839	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgmt Protein Structure

AdaB

0
100
209 a.a.

Protein Preferred Names

Protein Names

methylated-DNA--protein-cysteine methyltransferase

0-6-methylguanine-DNA methyltransferase	6-O-methylguanine-DNA methyltransferase
O(6)-alkylguanine-DNA alkyltransferase	O-6-methylguanine-DNA-alkyltransferase
O6-alkylguanine-DNA alkyltransferase	O6-methylguanine-DNA methyltranferase

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13668	Lomeguatrib	Inhibitor	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13057	O6BTG-octylglucoside	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mgmt	NCBI	NCBI:4255

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