Npy5r - neuropeptide Y receptor Y5 Gene

Rattus norvegicus

Also known as NPYR5

Gene ID: 25340 | Gene type: protein coding

About Npy5r

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues.

Summary

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Located in cytoplasm. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r Products(3)

mRNA	Protein	Name
NM_012869.2	NP_037001.1	neuropeptide Y receptor type 5
XM_006253014.4	XP_006253076.1	neuropeptide Y receptor type 5 isoform X1
NM_012869.2	NP_037001.1	neuropeptide Y receptor type 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide Y receptor activity	IDA IDA: Inferred from direct assay	8824284	RGD
enables pancreatic polypeptide receptor activity	IDA IDA: Inferred from direct assay	8824284	RGD
enables peptide YY receptor activity	IDA IDA: Inferred from direct assay	8824284	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	9795372	RGD
involved in generation of ovulation cycle rhythm	IMP IMP: Inferred from mutant phenotype	12047724	RGD
involved in negative regulation of acute inflammatory response to antigenic stimulus	IDA IDA: Inferred from direct assay	18805447	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12791184	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	12623227	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	11796508	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21595512	RGD
involved in positive regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	12161018	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21595512	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	12710532	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy5r Protein Structure

7tm_1

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

neuropeptide Y receptor type 5

NPY-Y5 receptor	NPY5-R
NPYY5-R	Neuropeptide Y5 receptor
Y5 receptor

Related Diseases

Diseases

Alias

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Dihydropyrimidinase Deficiency

Dihydropyrimidinuria	Dpys Deficiency
Dph Deficiency	DPYSD
Dihydrouracil Amidohydrolase Deficiency	Dihydropyrimidinuria Due To Dpys Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107734	L 152804	Antagonist	99.48%	Unkown
HY-RS09520	NPY5R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09521	Npy5r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09522	Npy5r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npy5r	NCBI	NCBI:4889

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