Oxtr - oxytocin receptor Gene

Rattus norvegicus

Also known as OTR; OT-R; OTR1

Gene ID: 25342 | Gene type: protein coding

About Oxtr

Primary_assembly 4: 145,599,561-145,614,674 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 265 orthologues, 16 paralogues and is associated with 25 phenotypes. Biased expression in Adrenal (RPKM 17.2), Uterus (RPKM 11.7) and 7 other tissues.

Summary

Enables Oxytocin Receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of synaptic transmission; and regulation of secretion. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (Oxytocin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Oxtr Products(1)

mRNA	Protein	Name
NM_012871.4	NP_037003.2	oxytocin receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	25539504	RGD
enables oxytocin receptor activity	IDA IDA: Inferred from direct assay	15821089	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	15821089	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9176188	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	10497238	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9575824	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	19003903	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	15380376	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	12867731	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	16832906	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15316117	RGD
involved in maternal behavior	IMP IMP: Inferred from mutant phenotype	18513132	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	18936075	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	18304743	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	10497238	RGD
involved in positive regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	14656297	RGD
involved in positive regulation of penile erection	IMP IMP: Inferred from mutant phenotype	18469843	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	16488155	RGD
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	11069593	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	18510735	RGD
involved in positive regulation of uterine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	19164477	RGD
involved in response to amphetamine	IMP IMP: Inferred from mutant phenotype	17383105	RGD
involved in response to anoxia	IMP IMP: Inferred from mutant phenotype	18655887	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	16677710	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	10994633	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19258489	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11264328	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	12700188	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	10856882	RGD
involved in response to steroid hormone	IMP IMP: Inferred from mutant phenotype	12588901	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12834913	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	17383105	RGD
involved in sperm ejaculation	IMP IMP: Inferred from mutant phenotype	18469843	RGD
involved in suckling behavior	IMP IMP: Inferred from mutant phenotype	19106214	RGD
involved in telencephalon development	IEP IEP: Inferred from expression pattern	11021977	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	19003903	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11456414	RGD
located in microvillus	IDA IDA: Inferred from direct assay	11456414	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Oxtr Protein Structure

7tmA_OT_R

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

oxytocin receptor

oxcytocin receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108678	TC OT 39		/	Unkown
HY-P4990	Pro8-Oxytocin	Activator	/	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	/	Unkown
HY-P5017	(Val3,Pro8)-Oxytocin	Agonist	/	Unkown
HY-RS09894	OXTR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09895	Oxtr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09896	Oxtr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oxtr	NCBI	NCBI:5021

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