2. Gene
  3. Faslg - Fas ligand Gene

Faslg - Fas ligand Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1

Gene ID: 25385 | Gene type: protein coding

About Faslg

Summary

Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic Cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]

Faslg Products(1)

mRNA Protein Name
NM_012908.1 NP_037040.1 tumor necrosis factor ligand superfamily member 6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables death receptor binding IPI
IPI: Inferred from physical interaction
15557468 RGD
enables tumor necrosis factor receptor binding IMP
IMP: Inferred from mutant phenotype
16154149 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
10029626 RGD
involved in endosomal lumen acidification IDA
IDA: Inferred from direct assay
18045865 RGD
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
16689665 RGD
involved in inflammatory cell apoptotic process IGI
IGI: Inferred from genetic interaction
16154149 RGD
involved in intracellular chloride ion homeostasis IDA
IDA: Inferred from direct assay
18045865 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18471522 RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18471522 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9858598 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
18692025 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17899301 RGD
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
15541714 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16563377 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 6

Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)

CD95 ligand

CD95L protein

Fas antigen ligand

Fas ligand (TNF superfamily, member 6)

Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)

Recombinant Faslg Proteins

Cat. No. Product Name Accession Purity
HY-P74156 Fas Ligand Protein, Rat (P.pastoris, His) P36940 (L104-L278) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99445 Asunercept Inhibitor 98.13% Phase 3
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04752 FASLG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Faslg NCBI NCBI:356
Mus musculus Faslg NCBI