CNIH2 - cornichon family AMPA receptor auxiliary protein 2 Gene

Homo sapiens

Also known as Cnil; CNIH-2

Gene ID: 254263 | Gene type: protein coding

About CNIH2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,278,175-66,284,206 (from NCBI)

This gene has 6 transcripts (splice variants), 185 orthologues and 4 paralogues. Biased expression in brain (RPKM 22.4), adrenal (RPKM 2.7) and 1 other tissue.

Summary

The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA Receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA Receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

CNIH2 Products(1)

mRNA	Protein	Name
NM_182553.3	NP_872359.1	protein cornichon homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20805473	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	20805473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH2 Protein Structure

Cornichon

0
100
160 a.a.

Protein Preferred Names

Protein Names

protein cornichon homolog 2

cornichon homolog 2

CNIH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNIH2	Q6PI25	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	CNIH2	Q6PI25	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	CNIH2	Q6PI25	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	CNIH2	Q6PI25	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	CNIH2	Q6PI25	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	CNIH2	Q6PI25	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	CNIH2	Q6PI25	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	CNIH2	Q6PI25	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	CNIH2	Q6PI25	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CNIH2	Q6PI25	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	CNIH2	Q6PI25	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	CNIH2	Q6PI25	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	CNIH2	Q6PI25	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02885	CNIH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNIH2	RGD	RGD:1304930
Canis familiaris	CNIH2	VGNC	VGNC:39400
Felis catus	CNIH2	VGNC	VGNC:61016
Macaca mulatta	CNIH2	VGNC	VGNC:71366
Mus musculus	CNIH2	MGD	MGI:1277225
Bos taurus	CNIH2	VGNC	VGNC:106695

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